Circuit-specific regulation of synapse formation by the protein tyrosine phosphatase PTP$\sigma$타이로신 탈인산화 효소 수용체 PTP$\sigma$에 의한 시냅스 기능 조절 연구

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dc.contributor.advisorKim, Eunjoon-
dc.contributor.advisor김은준-
dc.contributor.authorKim, Kyungdeok-
dc.date.accessioned2021-05-12T19:45:12Z-
dc.date.available2021-05-12T19:45:12Z-
dc.date.issued2020-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=924492&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/284427-
dc.description학위논문(박사) - 한국과학기술원 : 생명과학과, 2020.8,[iii, 95 p. :]-
dc.description.abstractCell Adhesion Molecule) initiates synapse formation via interacting with specific binding partners. However, functions of CAM during maintenance period and plasticity are shortly investigated. Here, I discovered an important presynaptic hub CAM, PTP$\sigma$, stabilizes NMDA-R in hippocampal SC-CA1 synapses by trans-synaptic manner, without affecting synapse formation. Surprisingly, this NMDA-R regulation works through intracellular domains and phosphatase activity of PTP$\sigma$, rather than famous extracellular bindings known to mediating synapse formation. Lacking PTP$\sigma$ causes broad range of phosphor-tyrosine level changes across the synaptic cleft, and one/many of those substrates is highly probable to mediate NMDA-R function regulation. In behavioral-wide, aberrant NMDA-R function in SC-CA1 by presynaptic KO of PTP$\sigma$, as well as postsynaptic KD of essential subunit of NMDA-R, causes impairment of novelty recognition.-
dc.description.abstractCAM (-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectSynapse▼aPTP$\sigma$▼aNMDA-R▼aCAM▼aphosphatase▼anovelty recognition-
dc.subject시냅스▼aPTP$\sigma$▼aNMDA 수용체▼a세포 접착 단백질▼a탈인산화 효소▼a새로움 인지-
dc.titleCircuit-specific regulation of synapse formation by the protein tyrosine phosphatase PTP$\sigma$-
dc.title.alternative타이로신 탈인산화 효소 수용체 PTP$\sigma$에 의한 시냅스 기능 조절 연구-
dc.typeThesis(Ph.D)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :생명과학과,-
dc.contributor.alternativeauthor김경덕-
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