Enhanced transdermal drug delivery system via bio-medical devices

Abstract

Transdermal drug delivery has advantages of topical drug administration compared to the other conventional administration methods. However, the skin penetration of drugs is limited by the barrier properties of stratum corneum. The combinational strategy has been investigated to improve the skin permeability of the drug. In this study, we have studied transdermal drug delivery system using physical enhancer such as sonophoresis, iontophoresis and microneedles. First, the enhancement effect of sonophoresis was evaluated for various cosmeceutical drugs. In addition, we confirmed that the simultaneous treatment of sonophoresis and iontophoresis enhanced skin penetration of glutamic acid. Second, we investigated that transdermal drug delivery system including 5-fluorouracil loaded carboxymethyl chitosan nanoparticles and microneedles for keloid treatment.