DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyung-Don | ko |
dc.contributor.author | Jeong, Seongju | ko |
dc.contributor.author | Park, Seongyeol | ko |
dc.contributor.author | Lee, Yong Joon | ko |
dc.contributor.author | Ju, Young Seok | ko |
dc.contributor.author | Kim, Danbee | ko |
dc.contributor.author | Song, Gi-Won | ko |
dc.contributor.author | Lee, Jae Hoon | ko |
dc.contributor.author | Kim, Sang-Yeob | ko |
dc.contributor.author | Shin, Jaehoon | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Hwang, Shin | ko |
dc.contributor.author | Yoo, Changhoon | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.date.accessioned | 2021-04-05T07:10:11Z | - |
dc.date.available | 2021-04-05T07:10:11Z | - |
dc.date.created | 2021-03-17 | - |
dc.date.created | 2021-03-17 | - |
dc.date.issued | 2021-04 | - |
dc.identifier.citation | LIVER INTERNATIONAL, v.41, no.4, pp.764 - 776 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | http://hdl.handle.net/10203/282304 | - |
dc.description.abstract | Background The heterogeneous immune landscapes of intrahepatic cholangiocarcinoma (ICC) remain largely unknown. Here we aimed to investigate the implications of tissue-resident memory (TRM)-related features of tumour-infiltrating CD8(+) T cells (CD8(+) TILs) from ICC patients. Methods From ICC patients, we obtained blood samples and ICC surgical specimens (n = 33). We performed multicolour flow cytometry, multiplexed immunohistochemistry and RNA sequencing. Results When compared to peripheral CD8(+) T cells, the CD8(+) TILs included significantly higher proportions of the CD69(+)CD103(-) and CD69(+)CD103(+) TRM-like subsets (P < .001 for both). Relative to CD69(-) and CD69(+)CD103(-) cells, the CD69(+)CD103(+) CD8(+) TILs harboured higher levels of T-cell markers representing tumour specificity (ie CD39), proliferation (ie Ki-67) and T-cell activation (ie HLA-DR and CD38) (all P < .001). Moreover, compared to the stroma, the tumour margin and core density each had a significantly higher density of CD103(+) CD8(+) TILs (P < .001 for both). ICCs with high proportions of CD69(+)CD103(+) cells displayed higher levels of parameters associated with response to immune checkpoint inhibitors (ICIs)-including number of CD8(+) TIL infiltrates (P = .019), PD-L1 expression in the tumour (P = .046) and expression of the T cell-inflamed gene signature (P < .001). ICCs with lower proportions of CD69(+)CD103(+) CD8(+) TILs exhibited significant enrichment of genes related to the Wnt/beta-catenin (P < .001) and TGF-beta pathways (P = .002). Conclusion CD69(+)CD103(+) TRM-like CD8(+) TILs represent prominent tumour-specific immune responses and hold promise as a potential therapeutic target in ICC patients. Differential TRM-related features of ICCs may help develop future immunotherapeutic strategies such as maximizing TRM responses or inhibiting pathways contributing to immune evasion. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.title | Implication of CD69(+)CD103(+) tissue-resident-like CD8(+) T cells as a potential immunotherapeutic target for cholangiocarcinoma | - |
dc.type | Article | - |
dc.identifier.wosid | 000620713100001 | - |
dc.identifier.scopusid | 2-s2.0-85101240901 | - |
dc.type.rims | ART | - |
dc.citation.volume | 41 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 764 | - |
dc.citation.endingpage | 776 | - |
dc.citation.publicationname | LIVER INTERNATIONAL | - |
dc.identifier.doi | 10.1111/liv.14814 | - |
dc.contributor.localauthor | Ju, Young Seok | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.nonIdAuthor | Kim, Danbee | - |
dc.contributor.nonIdAuthor | Song, Gi-Won | - |
dc.contributor.nonIdAuthor | Lee, Jae Hoon | - |
dc.contributor.nonIdAuthor | Kim, Sang-Yeob | - |
dc.contributor.nonIdAuthor | Shin, Jaehoon | - |
dc.contributor.nonIdAuthor | Hwang, Shin | - |
dc.contributor.nonIdAuthor | Yoo, Changhoon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cholangiocarcinoma | - |
dc.subject.keywordAuthor | immune checkpoint inhibitor | - |
dc.subject.keywordAuthor | tissue& | - |
dc.subject.keywordAuthor | #8208 | - |
dc.subject.keywordAuthor | resident memory T cells | - |
dc.subject.keywordAuthor | tumour& | - |
dc.subject.keywordAuthor | #8208 | - |
dc.subject.keywordAuthor | infiltrating lymphocytes | - |
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