DC Field | Value | Language |
---|---|---|
dc.contributor.author | Andika, Faris Rizky | ko |
dc.contributor.author | Yoon, Jin-Hui | ko |
dc.contributor.author | Kim, Sandy Gaon | ko |
dc.contributor.author | Jeong, Yong | ko |
dc.date.accessioned | 2021-04-02T02:30:14Z | - |
dc.date.available | 2021-04-02T02:30:14Z | - |
dc.date.created | 2020-11-10 | - |
dc.date.created | 2020-11-10 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.citation | JOURNAL OF NUTRITION, v.151, no.3, pp.722 - 730 | - |
dc.identifier.issn | 0022-3166 | - |
dc.identifier.uri | http://hdl.handle.net/10203/282263 | - |
dc.description.abstract | BACKGROUND: Intermittent fasting (IF) is found to exhibit neuroprotection against various insults, including ischemia; however, IF has been mainly applied before disease onset. It remains unknown whether IF implementation alleviates the long-term detrimental effects of a disease after its establishment. OBJECTIVES: To investigate the IF effects on cognitive impairments and cerebrovascular pathologies in a subcortical vascular dementia (SVaD) mouse model. METHODS: The SVaD model was developed by inducing hypoperfusion and hyperlipidemia in apoE-deficient (apoE-/-) mice. We subjected 10-week-old apoE-/- mice to bilateral common carotid artery stenosis using micro-coils after they were fed a high-fat diet (HFD; 45% energy) for 6 weeks to induce hyperlipidemia. Age-matched wild-type C57BL/6J mice received sham surgery after undergoing an identical HFD treatment. Both the SVaD model and wild-type mice either started a 1-month IF regimen (time-restricted feeding for 6 hours per day) or continued the standard diet ad libitum (6.2% fat energy) at 8 weeks post-surgery. We assessed mice weight, food intake, and outcomes in a behavioral test battery before, during, and after the IF regimen, prior to histopathological analyses (microvessel density, neuronal density, white matter damage, astrocytosis) of their brains. RESULTS: SVaD model mice on the IF regimen (SVaD-IF) exhibited higher mean recognition and spatial working memory performance compared to SVaD mice fed ad libitum (SVaD-AL; P < 0.01). Additionally, SVaD-IF mice had ∼5% higher hippocampal neuronal density in the dentate gyrus (DG) and cornu ammonis 1 regions than SVaD-AL mice (P < 0.001), which paralleled their post-IF cognitive enhancements. However, SVaD-IF mice showed an ∼50% increase in hippocampal DG astrocytosis compared to SVaD-AL mice (P < 0.05), with no significant differences in microvessel densities among the 2 groups. CONCLUSIONS: The improvements in SVaD-IF mice suggest that IF could be a potential nonpharmacological remedy for SVaD. This finding could stimulate future investigations on IF's neuroprotective potential across many neurovascular diseases. © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Intermittent Fasting Alleviates Cognitive Impairments and Hippocampal Neuronal Loss but Enhances Astrocytosis in Mice with Subcortical Vascular Dementia | - |
dc.type | Article | - |
dc.identifier.wosid | 000649736900034 | - |
dc.identifier.scopusid | 2-s2.0-85102909946 | - |
dc.type.rims | ART | - |
dc.citation.volume | 151 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 722 | - |
dc.citation.endingpage | 730 | - |
dc.citation.publicationname | JOURNAL OF NUTRITION | - |
dc.identifier.doi | 10.1093/jn/nxaa384 | - |
dc.contributor.localauthor | Jeong, Yong | - |
dc.contributor.nonIdAuthor | Andika, Faris Rizky | - |
dc.contributor.nonIdAuthor | Kim, Sandy Gaon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | astrocytosis | - |
dc.subject.keywordAuthor | intermittent fasting | - |
dc.subject.keywordAuthor | neuronal loss | - |
dc.subject.keywordAuthor | subcortical vascular dementia | - |
dc.subject.keywordAuthor | time-restricted feeding | - |
dc.subject.keywordPlus | DIETARY RESTRICTION | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | NEUROGENESIS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INCREASES | - |
dc.subject.keywordPlus | DEFICITS | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | RAT | - |
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