DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Sanghoon | ko |
dc.contributor.author | Lee, Seojin | ko |
dc.contributor.author | Choi, Wonjun | ko |
dc.contributor.author | Kim, Namhoon | ko |
dc.contributor.author | Hong, Sungwoo | ko |
dc.date.accessioned | 2021-03-30T02:50:09Z | - |
dc.date.available | 2021-03-30T02:50:09Z | - |
dc.date.created | 2021-03-17 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.citation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.60, pp.7873 - 7879 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | http://hdl.handle.net/10203/282209 | - |
dc.description.abstract | Through the formation of an electron donor-acceptor (EDA) complex, strain-release aminopyridylation of [1.1.1]propellane with N-aminopyridinium salts as bifunctional reagents enabled the direct installation of amino and pyridyl groups onto bicyclo[1.1.1]pentane (BCP) frameworks in the absence of an external photocatalyst. The robustness of this method to synthesize 1,3-aminopyridylated BCPs under mild and metal-free conditions is highlighted by the late-stage modification of structurally complex biorelevant molecules. Moreover, the strategy was extended to P-centered and CF3 radicals for the unprecedented incorporation of such functional groups with pyridine across the BCP core in a three-component coupling. This practical method lays the foundation for the straightforward construction of new valuable C4-pyridine-functionalized BCP chemical entities, thus significantly expanding the range of accessibility of BCP-type bioisosteres for applications in drug discovery. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Visible-Light-Induced 1,3-Aminopyridylation of [1.1.1]Propellane with N-Aminopyridinium Salts | - |
dc.type | Article | - |
dc.identifier.wosid | 000623512000001 | - |
dc.identifier.scopusid | 2-s2.0-85101904683 | - |
dc.type.rims | ART | - |
dc.citation.volume | 60 | - |
dc.citation.beginningpage | 7873 | - |
dc.citation.endingpage | 7879 | - |
dc.citation.publicationname | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.identifier.doi | 10.1002/anie.202016156 | - |
dc.contributor.localauthor | Hong, Sungwoo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | bicyclo[1 | - |
dc.subject.keywordAuthor | 1 | - |
dc.subject.keywordAuthor | 1]pentane | - |
dc.subject.keywordAuthor | bifunctional reagents | - |
dc.subject.keywordAuthor | photolysis | - |
dc.subject.keywordAuthor | pyridinium salts | - |
dc.subject.keywordAuthor | strained molecules | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.