DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jin Joo | ko |
dc.contributor.author | Park, Chan Soon | ko |
dc.contributor.author | Mebazaa, Alexandre | ko |
dc.contributor.author | Oh, Il-Young | ko |
dc.contributor.author | Park, Hyun-Ah | ko |
dc.contributor.author | Cho, Hyun-Jai | ko |
dc.contributor.author | Lee, Hae-Young | ko |
dc.contributor.author | Kim, Kye Hun | ko |
dc.contributor.author | Yoo, Byung-Su | ko |
dc.contributor.author | Kang, Seok-Min | ko |
dc.contributor.author | Baek, Sang Hong | ko |
dc.contributor.author | Jeon, Eun-Seok | ko |
dc.contributor.author | Kim, Jae-Joong | ko |
dc.contributor.author | Cho, Myeong-Chan | ko |
dc.contributor.author | Chae, Shung Chull | ko |
dc.contributor.author | Oh, Byung-Hee | ko |
dc.contributor.author | Choi, Dong-Ju | ko |
dc.date.accessioned | 2021-03-26T03:53:05Z | - |
dc.date.available | 2021-03-26T03:53:05Z | - |
dc.date.created | 2020-02-26 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | CLINICAL RESEARCH IN CARDIOLOGY, v.109, no.2, pp.225 - 234 | - |
dc.identifier.issn | 1861-0684 | - |
dc.identifier.uri | http://hdl.handle.net/10203/282111 | - |
dc.description.abstract | Objective Some patients with heart failure with preserved ejection fraction (HFpEF) experience declining of left-ventricular ejection fraction (LVEF) during follow-up. We aim to investigate the characteristics and outcomes of patients with HF with declining ejection fraction (HFdEF). Methods We analyzed a prospective, nationwide multicenter cohort with consecutive patients with acute HF enrolled from March 2011 to December 2014. HFpEF was defined as LVEF >= 50% at index admission. After 1 year, HFpEF patients were further classified as HFdEF (LVEF >= 50% at admission and < 50% at 1 year), and persistent HFpEF (LVEF >= 50% both at admission and 1 year). Primary outcome was 4-year all-cause mortality according to HF type from HFdEF diagnosis. Results Of patients with HFpEF, 426 (90.4%) were diagnosed as having persistent HFpEF and 45 (9.6%) as having HFdEF. Natriuretic peptide level was an independent predictor of HFdEF (natriuretic peptide level > median: odds ratio: 3.20, 95% confidence interval [CI]: 1.42-7.25, P = 0.005). During 4-year follow-up, patients with HFdEF had higher mortality than those with persistent HFpEF (Log-rank P < 0.001). After adjustment, HFdEF was associated with an almost twofold increased risk for mortality (hazard ratio 1.82, 95% CI 1.13-2.96, P = 0.015). The use of beta-blockers, renin-angiotensin system inhibitors, and mineralocorticoid receptor antagonists was not associated with improved prognosis of patients with HFdEF. Conclusions HFdEF is a distinct HF type with grave outcomes. Further investigations that focus on HFdEF are warranted to better understand and develop treatment strategies for these high-risk patients. Graphic abstract [GRAPHICS] . | - |
dc.language | English | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.title | Characteristics and outcomes of HFpEF with declining ejection fraction | - |
dc.type | Article | - |
dc.identifier.wosid | 000511949700008 | - |
dc.identifier.scopusid | 2-s2.0-85068735581 | - |
dc.type.rims | ART | - |
dc.citation.volume | 109 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 225 | - |
dc.citation.endingpage | 234 | - |
dc.citation.publicationname | CLINICAL RESEARCH IN CARDIOLOGY | - |
dc.identifier.doi | 10.1007/s00392-019-01505-y | - |
dc.contributor.nonIdAuthor | Park, Jin Joo | - |
dc.contributor.nonIdAuthor | Mebazaa, Alexandre | - |
dc.contributor.nonIdAuthor | Oh, Il-Young | - |
dc.contributor.nonIdAuthor | Park, Hyun-Ah | - |
dc.contributor.nonIdAuthor | Cho, Hyun-Jai | - |
dc.contributor.nonIdAuthor | Lee, Hae-Young | - |
dc.contributor.nonIdAuthor | Kim, Kye Hun | - |
dc.contributor.nonIdAuthor | Yoo, Byung-Su | - |
dc.contributor.nonIdAuthor | Kang, Seok-Min | - |
dc.contributor.nonIdAuthor | Baek, Sang Hong | - |
dc.contributor.nonIdAuthor | Jeon, Eun-Seok | - |
dc.contributor.nonIdAuthor | Kim, Jae-Joong | - |
dc.contributor.nonIdAuthor | Cho, Myeong-Chan | - |
dc.contributor.nonIdAuthor | Chae, Shung Chull | - |
dc.contributor.nonIdAuthor | Oh, Byung-Hee | - |
dc.contributor.nonIdAuthor | Choi, Dong-Ju | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Heart failure with declining ejection fraction | - |
dc.subject.keywordAuthor | Predictor | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Mortality | - |
dc.subject.keywordAuthor | Treatment | - |
dc.subject.keywordPlus | HEART-FAILURE PATIENTS | - |
dc.subject.keywordPlus | NT-PROBNP | - |
dc.subject.keywordPlus | PATHOPHYSIOLOGY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
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