DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Seok Jong | ko |
dc.contributor.author | Lee, Hye Sun | ko |
dc.contributor.author | Kim, Hang-Rai | ko |
dc.contributor.author | Yoo, Han Soo | ko |
dc.contributor.author | Lee, Yang Hyun | ko |
dc.contributor.author | Jung, Jin Ho | ko |
dc.contributor.author | Baik, KyoungWon | ko |
dc.contributor.author | Ye, Byoung Seok | ko |
dc.contributor.author | Sohn, Young H. | ko |
dc.contributor.author | Lee, Phil Hyu | ko |
dc.date.accessioned | 2021-03-26T01:57:01Z | - |
dc.date.available | 2021-03-26T01:57:01Z | - |
dc.date.created | 2020-11-03 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | NEUROLOGY, v.95, no.12, pp.E1650 - E1659 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | http://hdl.handle.net/10203/281881 | - |
dc.description.abstract | Objectives To investigate which baseline neuropsychological profile predicts the risk of developing dementia in early-stage Parkinson disease (PD). Methods We retrospectively reviewed detailed medical records of 350 drug-naive patients with early-stage PD (follow-up >3 years) who underwent a detailed neuropsychological test at initial assessment. Factor analysis was conducted to determine cognitive profiles that yielded 4 cognitive function factors: factor 1, visual memory/visuospatial; factor 2, verbal memory; factor 3, frontal/executive; and factor 4, attention/working memory/language. Subsequently, we assessed the effect of these cognitive function factors on the risk for dementia conversion. We also constructed a nomogram to calculate the risk for developing dementia over a 5-year follow-up period based on these cognitive profiles. Results Cox regression analysis demonstrated that a higher composite score of factor 1 (hazard ratio [HR] 0.558, 95% confidence interval [CI] 0.427-0.730), factor 2 (HR 0.768, 95% CI 0.596-0.991), and factor 3 (HR 0.425, 95% CI 0.305-0.593) was associated with a lower risk for dementia conversion, while factor 3 had the most predictive power. The nomogram had a fair ability (Heagerty integrated area under the curve 0.763) to estimate the risk for dementia conversion within 5 years. The composite scores of factor 3 contributed more to the occurrence of dementia in PD than those of the other cognitive function factors. Conclusions These findings suggest that these factor analysis-derived cognitive profiles can be used to predict dementia conversion in early-stage PD. In addition, frontal/executive dysfunction contributes most to the occurrence of dementia in PD. | - |
dc.language | English | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Factor analysis-derived cognitive profile predicting early dementia conversion in PD | - |
dc.type | Article | - |
dc.identifier.wosid | 000578286500015 | - |
dc.identifier.scopusid | 2-s2.0-85091470026 | - |
dc.type.rims | ART | - |
dc.citation.volume | 95 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | E1650 | - |
dc.citation.endingpage | E1659 | - |
dc.citation.publicationname | NEUROLOGY | - |
dc.identifier.doi | 10.1212/WNL.0000000000010347 | - |
dc.contributor.nonIdAuthor | Chung, Seok Jong | - |
dc.contributor.nonIdAuthor | Lee, Hye Sun | - |
dc.contributor.nonIdAuthor | Yoo, Han Soo | - |
dc.contributor.nonIdAuthor | Lee, Yang Hyun | - |
dc.contributor.nonIdAuthor | Jung, Jin Ho | - |
dc.contributor.nonIdAuthor | Baik, KyoungWon | - |
dc.contributor.nonIdAuthor | Ye, Byoung Seok | - |
dc.contributor.nonIdAuthor | Sohn, Young H. | - |
dc.contributor.nonIdAuthor | Lee, Phil Hyu | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | DIAGNOSTIC-CRITERIA | - |
dc.subject.keywordPlus | VERBAL FLUENCY | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | DECLINE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | DISORDER | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | CAMPAIGN | - |
dc.subject.keywordPlus | IMPACT | - |
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