Efficient Construction of a Chemical Reaction Network Guided By a Monte Carlo Tree Search

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Chemical reaction networks are essential for the complete elucidation of chemical reaction mechanisms. Graph‐theoretic methods combined with quantum calculations are known to be an efficient approach with broad applicability for constructing reaction networks. However, this method entails high computational cost due to quantum calculations on chemically irrelevant intermediates coming from the exploration of a large scale chemical space. To remedy this problem, we propose to apply the Monte Carlo tree search algorithm to those graph‐theoretic methods. We have combined it with ACE‐Reaction, our in‐house graph‐theoretic method, and demonstrated its performance on five organic reactions. The result shows that the computational cost for quantum calculations has been reduced by up to 75 % from that of the original ACE‐Reaction. Furthermore, cost reduction became more efficient for more complex reactions.
Publisher
Wiley
Issue Date
2020-09
Language
English
Citation

ChemSystemsChem, v.2, no.5, pp.e1900057

ISSN
2570-4206
DOI
10.1002/syst.201900057
URI
http://hdl.handle.net/10203/281697
Appears in Collection
CH-Journal Papers(저널논문)
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