DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Min Soo | ko |
dc.contributor.author | Han, Jin-Hee | ko |
dc.date.accessioned | 2021-02-08T02:10:06Z | - |
dc.date.available | 2021-02-08T02:10:06Z | - |
dc.date.created | 2021-02-03 | - |
dc.date.created | 2021-02-03 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.citation | MOLECULAR BRAIN, v.14, no.1 | - |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | http://hdl.handle.net/10203/280634 | - |
dc.description.abstract | Formation of temporal association memory and context-specific fear memory is thought to require medial entorhinal cortex (MEC) inputs to the hippocampus during learning events. However, whether the MEC inputs are also involved in memory formation during a post-learning period has not been directly tested yet. To examine this possibility, we optogenetically inhibited axons and terminals originating from bilateral dorsal MEC excitatory neurons in the dorsal hippocampus for 5 min right after contextual fear conditioning (CFC). Mice expressing eNpHR3.0 exhibited significantly less freezing compared to control mice expressing EGFP alone during retrieval test in the conditioned context 1 day after learning. In contrast, the same optogenetic inhibition of MEC inputs performed 30 min before retrieval test did not affect freezing during retrieval test, excluding the possibility of non-specific deleterious effect of optical inhibition on retrieval process. These results support that contextual fear memory formation requires MEC inputs to the hippocampus during a post-learning period. | - |
dc.language | English | - |
dc.publisher | BMC | - |
dc.title | Optogenetic inhibition of medial entorhinal cortex inputs to the hippocampus during a short period of time right after learning disrupts contextual fear memory formation | - |
dc.type | Article | - |
dc.identifier.wosid | 000608119400001 | - |
dc.identifier.scopusid | 2-s2.0-85098783674 | - |
dc.type.rims | ART | - |
dc.citation.volume | 14 | - |
dc.citation.issue | 1 | - |
dc.citation.publicationname | MOLECULAR BRAIN | - |
dc.identifier.doi | 10.1186/s13041-020-00719-w | - |
dc.contributor.localauthor | Han, Jin-Hee | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Medial entorhinal cortex | - |
dc.subject.keywordAuthor | Hippocampus | - |
dc.subject.keywordAuthor | Contextual fear conditioning | - |
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