DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Seongmin | ko |
dc.contributor.author | Yi, Yelim | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2021-02-01T06:50:11Z | - |
dc.date.available | 2021-02-01T06:50:11Z | - |
dc.date.created | 2021-01-04 | - |
dc.date.created | 2021-01-04 | - |
dc.date.created | 2021-01-04 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.citation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.42, no.1, pp.17 - 24 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | http://hdl.handle.net/10203/280423 | - |
dc.description.abstract | Aggregates of both metal-free amyloid-beta (A beta) and metal-bound A beta (metal-A beta) are accumulated in the brain affected by Alzheimer's disease. To control metal-free and metal-bound A beta species, chemical reagents capable of modulating their aggregation profiles have been developed. As an effort, the reactivity of natural products such as flavonoids with metal-free A beta and metal-A beta has been investigated to identify their use as chemical reagents and structural features essential for such reactivity. This review illustrates the effects of flavonoids containing a catechol or pyrogallol group on metal-free and metal-mediated A beta aggregation pathways. In addition, the studies regarding the structure-activity relationship of flavonoids against metal-free A beta or metal-A beta are discussed. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Reactivity of Flavonoids Containing a Catechol or Pyrogallol Moiety with Metal-Free and Metal-Associated Amyloid-beta | - |
dc.type | Article | - |
dc.identifier.wosid | 000598330900001 | - |
dc.identifier.scopusid | 2-s2.0-85097498555 | - |
dc.type.rims | ART | - |
dc.citation.volume | 42 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 17 | - |
dc.citation.endingpage | 24 | - |
dc.citation.publicationname | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.identifier.doi | 10.1002/bkcs.12172 | - |
dc.identifier.kciid | ART002679950 | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Park, Seongmin | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Review; Early Access | - |
dc.subject.keywordAuthor | Flavonoids | - |
dc.subject.keywordAuthor | Catechol group | - |
dc.subject.keywordAuthor | Amyloid& | - |
dc.subject.keywordAuthor | #8208 | - |
dc.subject.keywordAuthor | & | - |
dc.subject.keywordAuthor | #946 | - |
dc.subject.keywordAuthor | Metal ions | - |
dc.subject.keywordAuthor | Alzheimer& | - |
dc.subject.keywordAuthor | apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | A-BETA | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | IONS | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | FIBRILS | - |
dc.subject.keywordPlus | COPPER | - |
dc.subject.keywordPlus | (-)-EPIGALLOCATECHIN-3-GALLATE | - |
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