DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Chung, Jong-Kyeong | - |
dc.contributor.advisor | 정종경 | - |
dc.contributor.author | Lee, Ji-Woon | - |
dc.contributor.author | 이지운 | - |
dc.date.accessioned | 2011-12-12T08:53:59Z | - |
dc.date.available | 2011-12-12T08:53:59Z | - |
dc.date.issued | 2004 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=237822&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/28029 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생명과학과, 2004.2, [ iv, 53 p. ] | - |
dc.description.abstract | It is well known that the FOXO subfamily of forkhead transcription factors play a critical role in cell cycle, apoptosis, and energy metabolism, and are important for mediating effects of insulin and growth factors on gene expression as a downstream target of phosphatidylinositol 3-kinase (PI3K) and Akt. Here, I found a novel regulator of FOXO transcription factor, CRK, through genetic screening. Through coimmunoprecipitation analyses, I demonstrated that FKHR directly interacts with CRK in vivo, and that the C-terminal of CRK is needed for interaction with FKHR. Furthermore, I examined the regulation of CRK on FKHR; I revealed that CRK phosphorylates and thus, inhibits FKHR-dependent transcription in a kinase-activity-dependent manner, and that CRK induces the nuclear exclusion of FKHR by export mechanism using immunocytochemical analyses. Collectively, these findings establish CRK as a new regulator of FKHR. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | PI3K SIGNALING PATHWAY | - |
dc.subject | FOXO TRANSCRIPTION FACTOR | - |
dc.subject | AKT | - |
dc.subject | Akt 인산화 효소 | - |
dc.subject | PI3K 신호 전달 | - |
dc.subject | FOXO 전사 인자 | - |
dc.title | Regulation of FOXO transcription factor | - |
dc.title.alternative | FOXO 전사 인자의 조절 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 237822/325007 | - |
dc.description.department | 한국과학기술원 : 생명과학과, | - |
dc.identifier.uid | 020023489 | - |
dc.contributor.localauthor | Chung, Jong-Kyeong | - |
dc.contributor.localauthor | 정종경 | - |
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