We study the effect of satellite operations on the Upsilon invariant of Ozsvath-Stipsicz-Szabo. We obtain results concerning when a knot and its satellites are independent; for example, we show that the set {D2i,1}i=1 infinity is a basis for an infinite rank summand of the group of smooth concordance classes of topologically slice knots, for D the positive clasped untwisted Whitehead double of any knot with positive tau-invariant, e.g. the right-handed trefoil. We also prove that the image of the Mazur satellite operator on the smooth knot concordance group contains an infinite rank subgroup of topologically slice knots.