DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Chung, An-Sik | - |
dc.contributor.advisor | 정안식 | - |
dc.contributor.author | Kim, Kyu-Han | - |
dc.contributor.author | 김규한 | - |
dc.date.accessioned | 2011-12-12T08:53:44Z | - |
dc.date.available | 2011-12-12T08:53:44Z | - |
dc.date.issued | 2004 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=237805&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/28012 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생명과학과, 2004.2, [ vi, 49 p. ] | - |
dc.description.abstract | Metastasis is the main cause of death in cancer patients. Active matrix metalloproteinases (MMPs) play a key role in tumor invasion. Many studied have tried to examine the role of peroxisome proliferator-activated receptor γ (PPARγ) in cancer. But it is still a debatable issue. Here, we report for the first time that ciglitazone induced pro-MMP-2 activation through induction of memebrane type 1-MMP (MT1-MMP) expression and increased the invasiveness of tumor in HT1080 cell but not the other PPARγ agonists of thiazolidinedione (TZD) class. Ciglitazone activated strongly PPAR_γ. But MMP-2 activation was not relevant to PPAR_γ activation. To investigate the mechanism of MMP-2 activation by ciglitazone, various antioxidants and signal inhibitors are pre-treated. So, we find that ciglitazone induced pro-MMP-2 activation by the sustained production of $H_2O_2$. And it was also regulated by ERK/NF-κB pathway. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | MMP-2 ACTIVITY | - |
dc.subject | 활성 조절 | - |
dc.subject | PPARG AGONIST | - |
dc.title | Regulation of MMP-2 activity in response to treatment of $PPAR_γ$ agonists | - |
dc.title.alternative | $PPAR_γ$ agonists에 의한 MMP-2 활성 조절에 관한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 237805/325007 | - |
dc.description.department | 한국과학기술원 : 생명과학과, | - |
dc.identifier.uid | 020023042 | - |
dc.contributor.localauthor | Chung, An-Sik | - |
dc.contributor.localauthor | 정안식 | - |
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