DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Jinwon | ko |
dc.contributor.author | Lee, Changseok | ko |
dc.contributor.author | Seo, Huiyeong | ko |
dc.contributor.author | Hong, Sungwoo | ko |
dc.date.accessioned | 2020-12-31T02:30:09Z | - |
dc.date.available | 2020-12-31T02:30:09Z | - |
dc.date.created | 2020-12-29 | - |
dc.date.created | 2020-12-29 | - |
dc.date.created | 2020-12-29 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.142, no.48, pp.20470 - 20480 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10203/279381 | - |
dc.description.abstract | Reported herein is a modular, NiH-catalyzed system capable of proximal-selective hydroamination of unactivated alkenes with diverse amine sources. The key to the successful implementation of this approach is the promotion of NiH insertion into even highly substituted olefins via coordination of the bidentate directing group to the nickel complex. A wide range of primary and secondary amines can be installed in both internal and terminal unactivated alkenes with excellent regiocontrol under the optimized reaction conditions. This protocol is flexible and general for the preparation of a variety of valuable β- and γ-amino acid building blocks that would otherwise be difficult to synthesize. The utility of this transformation was further demonstrated by the site-selective late-stage modification of complex and medicinally relevant molecules. Combined experimental and computational studies illuminate the detailed reaction mechanism. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | NiH-Catalyzed Proximal-Selective Hydroamination of Unactivated Alkenes | - |
dc.type | Article | - |
dc.identifier.wosid | 000596904700024 | - |
dc.identifier.scopusid | 2-s2.0-85096523427 | - |
dc.type.rims | ART | - |
dc.citation.volume | 142 | - |
dc.citation.issue | 48 | - |
dc.citation.beginningpage | 20470 | - |
dc.citation.endingpage | 20480 | - |
dc.citation.publicationname | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.identifier.doi | 10.1021/jacs.0c10333 | - |
dc.contributor.localauthor | Hong, Sungwoo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ANTI-MARKOVNIKOV HYDROAMINATION | - |
dc.subject.keywordPlus | INTRAMOLECULAR HYDROAMINATION | - |
dc.subject.keywordPlus | INTERMOLECULAR HYDROAMINATION | - |
dc.subject.keywordPlus | ASYMMETRIC HYDROAMINATION | - |
dc.subject.keywordPlus | FORMAL HYDROAMINATION | - |
dc.subject.keywordPlus | C(SP(3))-H BONDS | - |
dc.subject.keywordPlus | TERMINAL ALKENES | - |
dc.subject.keywordPlus | DIRECT ARYLATION | - |
dc.subject.keywordPlus | HECK ARYLATIONS | - |
dc.subject.keywordPlus | ALKYL | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.