DC Field | Value | Language |
---|---|---|
dc.contributor.author | Krishnan, Siddharth R. | ko |
dc.contributor.author | Arafa, Hany M. | ko |
dc.contributor.author | Kwon, Kyeongha | ko |
dc.contributor.author | Deng, Yujun | ko |
dc.contributor.author | Su, Chun-Ju | ko |
dc.contributor.author | Reeder, Jonathan T. | ko |
dc.contributor.author | Freudman, Juliet | ko |
dc.contributor.author | Stankiewicz, Izabela | ko |
dc.contributor.author | Chen, Hsuan-Ming | ko |
dc.contributor.author | Loza, Robert | ko |
dc.contributor.author | Mims, Marcus | ko |
dc.contributor.author | Mims, Mitchell | ko |
dc.contributor.author | Lee, KunHyuck | ko |
dc.contributor.author | Abecassis, Zachary | ko |
dc.contributor.author | Banks, Aaron | ko |
dc.contributor.author | Ostojich, Diana | ko |
dc.contributor.author | Patel, Manish | ko |
dc.contributor.author | Wang, Heling | ko |
dc.contributor.author | Borekci, Kaan | ko |
dc.contributor.author | Rosenow, Joshua | ko |
dc.contributor.author | Tate, Matthew | ko |
dc.contributor.author | Huang, Yonggang | ko |
dc.contributor.author | Alden, Tord | ko |
dc.contributor.author | Potts, Matthew B. | ko |
dc.contributor.author | Ayer, Amit B. | ko |
dc.contributor.author | Rogers, John A. | ko |
dc.date.accessioned | 2020-12-04T05:30:05Z | - |
dc.date.available | 2020-12-04T05:30:05Z | - |
dc.date.created | 2020-12-04 | - |
dc.date.created | 2020-12-04 | - |
dc.date.created | 2020-12-04 | - |
dc.date.created | 2020-12-04 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | NPJ DIGITAL MEDICINE, v.3, no.1 | - |
dc.identifier.issn | 2398-6352 | - |
dc.identifier.uri | http://hdl.handle.net/10203/278060 | - |
dc.description.abstract | Hydrocephalus is a common disorder caused by the buildup of cerebrospinal fluid (CSF) in the brain. Treatment typically involves the surgical implantation of a pressure-regulated silicone tube assembly, known as a shunt. Unfortunately, shunts have extremely high failure rates and diagnosing shunt malfunction is challenging due to a combination of vague symptoms and a lack of a convenient means to monitor flow. Here, we introduce a wireless, wearable device that enables precise measurements of CSF flow, continuously or intermittently, in hospitals, laboratories or even in home settings. The technology exploits measurements of thermal transport through near-surface layers of skin to assess flow, with a soft, flexible, and skin-conformal device that can be constructed using commercially available components. Systematic benchtop studies and numerical simulations highlight all of the key considerations. Measurements on 7 patients establish high levels of functionality, with data that reveal time dependent changes in flow associated with positional and inertial effects on the body. Taken together, the results suggest a significant advance in monitoring capabilities for patients with shunted hydrocephalus, with potential for practical use across a range of settings and circumstances, and additional utility for research purposes in studies of CSF hydrodynamics. | - |
dc.language | English | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Continuous, noninvasive wireless monitoring of flow of cerebrospinal fluid through shunts in patients with hydrocephalus | - |
dc.type | Article | - |
dc.identifier.wosid | 000519040400002 | - |
dc.identifier.scopusid | 2-s2.0-85088419084 | - |
dc.type.rims | ART | - |
dc.citation.volume | 3 | - |
dc.citation.issue | 1 | - |
dc.citation.publicationname | NPJ DIGITAL MEDICINE | - |
dc.identifier.doi | 10.1038/s41746-020-0239-1 | - |
dc.contributor.localauthor | Kwon, Kyeongha | - |
dc.contributor.nonIdAuthor | Krishnan, Siddharth R. | - |
dc.contributor.nonIdAuthor | Arafa, Hany M. | - |
dc.contributor.nonIdAuthor | Deng, Yujun | - |
dc.contributor.nonIdAuthor | Su, Chun-Ju | - |
dc.contributor.nonIdAuthor | Reeder, Jonathan T. | - |
dc.contributor.nonIdAuthor | Freudman, Juliet | - |
dc.contributor.nonIdAuthor | Stankiewicz, Izabela | - |
dc.contributor.nonIdAuthor | Chen, Hsuan-Ming | - |
dc.contributor.nonIdAuthor | Loza, Robert | - |
dc.contributor.nonIdAuthor | Mims, Marcus | - |
dc.contributor.nonIdAuthor | Mims, Mitchell | - |
dc.contributor.nonIdAuthor | Lee, KunHyuck | - |
dc.contributor.nonIdAuthor | Abecassis, Zachary | - |
dc.contributor.nonIdAuthor | Banks, Aaron | - |
dc.contributor.nonIdAuthor | Ostojich, Diana | - |
dc.contributor.nonIdAuthor | Patel, Manish | - |
dc.contributor.nonIdAuthor | Wang, Heling | - |
dc.contributor.nonIdAuthor | Borekci, Kaan | - |
dc.contributor.nonIdAuthor | Rosenow, Joshua | - |
dc.contributor.nonIdAuthor | Tate, Matthew | - |
dc.contributor.nonIdAuthor | Huang, Yonggang | - |
dc.contributor.nonIdAuthor | Alden, Tord | - |
dc.contributor.nonIdAuthor | Potts, Matthew B. | - |
dc.contributor.nonIdAuthor | Ayer, Amit B. | - |
dc.contributor.nonIdAuthor | Rogers, John A. | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | THRESHOLDS | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | PATENCY | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | CARE | - |
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