DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sujin | ko |
dc.contributor.author | Lee, Keonyong | ko |
dc.contributor.author | Choi, Yongseok | ko |
dc.contributor.author | Ku, Jayoung | ko |
dc.contributor.author | Lee, Yunjong | ko |
dc.contributor.author | Kim, Yoosik | ko |
dc.date.accessioned | 2020-12-02T00:50:26Z | - |
dc.date.available | 2020-12-02T00:50:26Z | - |
dc.date.created | 2020-11-30 | - |
dc.date.issued | 2020-10-07 | - |
dc.identifier.citation | 2020 International Conference: Korean Society for Molecular and Cellular Biology, pp.86 | - |
dc.identifier.uri | http://hdl.handle.net/10203/277898 | - |
dc.description.abstract | Protein kinase R (PKR) is an immune response protein that becomes activated by long double-stranded RNAs (dsRNAs). Several studies reported the misactivation of PKR in patients of degenerative diseases including primary osteoarthritis (OA). However, the molecular identity of PKR-activating dsRNAs remains unknown. Here, we investigate the role of mitochondrial dsRNAs (mt-dsRNAs) in the development of OA. We find that in response to OA-mimicking stressors, cytosolic efflux of mt-dsRNAs is increased, leading to PKR activation and subsequent induction of inflammatory cytokines and apoptosis. Moreover, mt-dsRNAs are exported to the extracellular space where they activate toll-like receptor 3. Elevated expression of mt-dsRNAs in the synovial fluids of OA patients further supports our data. Lastly, we show that autophagy protects chondrocytes from mitochondrial dysfunction partly by removing cytosolic mt-dsRNAs. Together, these findings establish the PKR-mt-dsRNA as a critical regulatory axis in OA development and suggest mt-dsRNAs as a potential target in fighting OA. | - |
dc.language | English | - |
dc.publisher | Korean Society for Molecular and Cellular Biology | - |
dc.title | Mitochondrial dsRNAs activate PKR and TLR3 to promote chondrocyte degeneration in osteoarthritis | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.beginningpage | 86 | - |
dc.citation.endingpage | 86 | - |
dc.citation.publicationname | 2020 International Conference: Korean Society for Molecular and Cellular Biology | - |
dc.identifier.conferencecountry | KO | - |
dc.identifier.conferencelocation | Virtual | - |
dc.contributor.localauthor | Kim, Yoosik | - |
dc.contributor.nonIdAuthor | Choi, Yongseok | - |
dc.contributor.nonIdAuthor | Lee, Yunjong | - |
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