DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Gunhee | ko |
dc.contributor.author | Lelong, Evan | ko |
dc.contributor.author | Kang, Juhye | ko |
dc.contributor.author | Suh, Jong-Min | ko |
dc.contributor.author | Le Bris, Nathalie | ko |
dc.contributor.author | Bernard, Helene | ko |
dc.contributor.author | Kim, Dongwook | ko |
dc.contributor.author | Tripier, Raphael | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2020-11-30T08:30:10Z | - |
dc.date.available | 2020-11-30T08:30:10Z | - |
dc.date.created | 2020-10-29 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | INORGANIC CHEMISTRY FRONTIERS, v.7, no.21, pp.4222 - 4238 | - |
dc.identifier.issn | 2052-1553 | - |
dc.identifier.uri | http://hdl.handle.net/10203/277751 | - |
dc.description.abstract | Amyloid-beta (A beta) aggregation and metal ion dyshomeostasis are found to be pathological features upon the progress of Alzheimer's disease (AD). In addition, A beta and metal ions are reported to interact with each other forming metal-A beta complexes, which can affect the aggregation of A beta and cause oxidative stress via the production of reactive oxygen species (ROS). To disrupt metal coordination to A beta and control the reactivities of metal-A beta, metal chelating agents have been tested. Herein, a series of azamacrocyclic compounds with different properties of Cu(ii) and Zn(ii) binding and A beta interaction were rationally selected under criteria based on structural and functional variations on the backbone of Cyclam. The series contains Cyclam, its N-methylated and cross-bridged (N-methylated or not) analogs, as well as their C-appended hydroxyethyl derivatives, and some of them have been newly synthesized. The reactivities of the cyclam derivatives towards the aggregation of metal-A beta and the generation of ROS mediated by metal-A beta were evaluated. Their modulative reactivities towards metal-A beta could be achieved by generating a ternary complex with metal-A beta and chelating the metal ion from metal-A beta. Moreover, the toxicity induced by metal-A beta in living cells was alleviated by the cyclam derivatives capable of regulating metal-A beta aggregation and metal-A beta-triggered ROS formation. Overall, our studies illustrate new examples of azamacrocyclic metal chelators that alter the interactions between metal ions and A beta and subsequently modify the reactivities of metal-A beta, with an indication of how the slight structure-property difference can influence such effects of small molecules. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Reactivities of cyclam derivatives with metal-amyloid-beta | - |
dc.type | Article | - |
dc.identifier.wosid | 000585823500016 | - |
dc.identifier.scopusid | 2-s2.0-85095118996 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 21 | - |
dc.citation.beginningpage | 4222 | - |
dc.citation.endingpage | 4238 | - |
dc.citation.publicationname | INORGANIC CHEMISTRY FRONTIERS | - |
dc.identifier.doi | 10.1039/d0qi00791a | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Lelong, Evan | - |
dc.contributor.nonIdAuthor | Kang, Juhye | - |
dc.contributor.nonIdAuthor | Le Bris, Nathalie | - |
dc.contributor.nonIdAuthor | Bernard, Helene | - |
dc.contributor.nonIdAuthor | Kim, Dongwook | - |
dc.contributor.nonIdAuthor | Tripier, Raphael | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CROSS-BRIDGED CYCLAM | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | COORDINATION CHEMISTRY | - |
dc.subject.keywordPlus | A-BETA | - |
dc.subject.keywordPlus | ZINC(II) COMPLEXES | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | SMALL MOLECULES | - |
dc.subject.keywordPlus | COPPER(II) | - |
dc.subject.keywordPlus | LIGANDS | - |
dc.subject.keywordPlus | PEPTIDE | - |
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