DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lucas, Carolina | ko |
dc.contributor.author | Wong, Patrick | ko |
dc.contributor.author | Klein, Jon | ko |
dc.contributor.author | Castro, Tiago B. R. | ko |
dc.contributor.author | Silva, Julio | ko |
dc.contributor.author | Sundaram, Maria | ko |
dc.contributor.author | Ellingson, Mallory K. | ko |
dc.contributor.author | Mao, Tianyang | ko |
dc.contributor.author | Oh, Ji Eun | ko |
dc.contributor.author | Israelow, Benjamin | ko |
dc.contributor.author | Takahashi, Takehiro | ko |
dc.contributor.author | Tokuyama, Maria | ko |
dc.contributor.author | Lu, Peiwen | ko |
dc.contributor.author | Venkataraman, Arvind | ko |
dc.contributor.author | Park, Annsea | ko |
dc.contributor.author | Mohanty, Subhasis | ko |
dc.contributor.author | Wang, Haowei | ko |
dc.contributor.author | Wyllie, Anne L. | ko |
dc.contributor.author | Vogels, Chantal B. F. | ko |
dc.contributor.author | Earnest, Rebecca | ko |
dc.contributor.author | Lapidus, Sarah | ko |
dc.contributor.author | Ott, Isabel M. | ko |
dc.contributor.author | Moore, Adam J. | ko |
dc.contributor.author | Muenker, M. Catherine | ko |
dc.contributor.author | Fournier, John B. | ko |
dc.contributor.author | Campbell, Melissa | ko |
dc.contributor.author | Odio, Camila D. | ko |
dc.contributor.author | Casanovas-Massana, Arnau | ko |
dc.contributor.author | Herbst, Roy | ko |
dc.contributor.author | Shaw, Albert C. | ko |
dc.contributor.author | Medzhitov, Ruslan | ko |
dc.contributor.author | Schulz, Wade L. | ko |
dc.contributor.author | Grubaugh, Nathan D. | ko |
dc.contributor.author | Dela Cruz, Charles | ko |
dc.contributor.author | Farhadian, Shelli | ko |
dc.contributor.author | Ko, Albert I. | ko |
dc.contributor.author | Omer, Saad B. | ko |
dc.contributor.author | Iwasaki, Akiko | ko |
dc.contributor.author | Obaid, Abeer | ko |
dc.contributor.author | Lu-Culligan, Alice | ko |
dc.contributor.author | Nelson, Allison | ko |
dc.contributor.author | Brito, Anderson | ko |
dc.contributor.author | Nunez, Angela | ko |
dc.contributor.author | Martin, Anjelica | ko |
dc.contributor.author | Watkins, Annie | ko |
dc.contributor.author | Geng, Bertie | ko |
dc.contributor.author | Kalinich, Chaney | ko |
dc.contributor.author | Harden, Christina | ko |
dc.contributor.author | Todeasa, Codruta | ko |
dc.contributor.author | Jensen, Cole | ko |
dc.contributor.author | Kim, Daniel | ko |
dc.contributor.author | McDonald, David | ko |
dc.contributor.author | Shepard, Denise | ko |
dc.contributor.author | Courchaine, Edward | ko |
dc.contributor.author | White, Elizabeth B. | ko |
dc.contributor.author | Song, Eric | ko |
dc.contributor.author | Silva, Erin | ko |
dc.contributor.author | Kudo, Eriko | ko |
dc.contributor.author | DeIuliis, Giuseppe | ko |
dc.contributor.author | Rahming, Harold | ko |
dc.contributor.author | Park, Hong-Jai | ko |
dc.contributor.author | Matos, Irene | ko |
dc.contributor.author | Nouws, Jessica | ko |
dc.contributor.author | Valdez, Jordan | ko |
dc.contributor.author | Fauver, Joseph | ko |
dc.contributor.author | Lim, Joseph | ko |
dc.contributor.author | Rose, Kadi-Ann | ko |
dc.contributor.author | Anastasio, Kelly | ko |
dc.contributor.author | Brower, Kristina | ko |
dc.contributor.author | Glick, Laura | ko |
dc.contributor.author | Sharma, Lokesh | ko |
dc.contributor.author | Sewanan, Lorenzo | ko |
dc.contributor.author | Knaggs, Lynda | ko |
dc.contributor.author | Minasyan, Maksym | ko |
dc.contributor.author | Batsu, Maria | ko |
dc.contributor.author | Petrone, Mary | ko |
dc.contributor.author | Kuang, Maxine | ko |
dc.contributor.author | Nakahata, Maura | ko |
dc.contributor.author | Campbell, Melissa | ko |
dc.contributor.author | Linehan, Melissa | ko |
dc.contributor.author | Askenase, Michael H. | ko |
dc.contributor.author | Simonov, Michael | ko |
dc.contributor.author | Smolgovsky, Mikhail | ko |
dc.contributor.author | Sonnert, Nicole | ko |
dc.contributor.author | Naushad, Nida | ko |
dc.contributor.author | Vijayakumar, Pavithra | ko |
dc.contributor.author | Martinello, Rick | ko |
dc.contributor.author | Datta, Rupak | ko |
dc.contributor.author | Handoko, Ryan | ko |
dc.contributor.author | Bermejo, Santos | ko |
dc.contributor.author | Prophet, Sarah | ko |
dc.contributor.author | Bickerton, Sean | ko |
dc.contributor.author | Velazquez, Sofia | ko |
dc.contributor.author | Alpert, Tara | ko |
dc.contributor.author | Rice, Tyler | ko |
dc.contributor.author | Khoury-Hanold, William | ko |
dc.contributor.author | Peng, Xiaohua | ko |
dc.contributor.author | Yang, Yexin | ko |
dc.contributor.author | Cao, Yiyun | ko |
dc.contributor.author | Strong, Yvette | ko |
dc.date.accessioned | 2020-11-18T02:55:05Z | - |
dc.date.available | 2020-11-18T02:55:05Z | - |
dc.date.created | 2020-11-16 | - |
dc.date.created | 2020-11-16 | - |
dc.date.created | 2020-11-16 | - |
dc.date.created | 2020-11-16 | - |
dc.date.created | 2020-11-16 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.citation | NATURE, v.584, no.7821, pp.463 - 469 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10203/277337 | - |
dc.description.abstract | Recent studies have provided insights into the pathogenesis of coronavirus disease 2019 (COVID-19)(1-4). However, the longitudinal immunological correlates of disease outcome remain unclear. Here we serially analysed immune responses in 113 patients with moderate or severe COVID-19. Immune profiling revealed an overall increase in innate cell lineages, with a concomitant reduction in T cell number. An early elevation in cytokine levels was associated with worse disease outcomes. Following an early increase in cytokines, patients with moderate COVID-19 displayed a progressive reduction in type 1 (antiviral) and type 3 (antifungal) responses. By contrast, patients with severe COVID-19 maintained these elevated responses throughout the course of the disease. Moreover, severe COVID-19 was accompanied by an increase in multiple type 2 (anti-helminths) effectors, including interleukin-5 (IL-5), IL-13, immunoglobulin E and eosinophils. Unsupervised clustering analysis identified four immune signatures, representing growth factors (A), type-2/3 cytokines (B), mixed type-1/2/3 cytokines (C), and chemokines (D) that correlated with three distinct disease trajectories. The immune profiles of patients who recovered from moderate COVID-19 were enriched in tissue reparative growth factor signature A, whereas the profiles of those with who developed severe disease had elevated levels of all four signatures. Thus, we have identified a maladapted immune response profile associated with severe COVID-19 and poor clinical outcome, as well as early immune signatures that correlate with divergent disease trajectories. | - |
dc.language | English | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Longitudinal analyses reveal immunological misfiring in severe COVID-19 | - |
dc.type | Article | - |
dc.identifier.wosid | 000559369800001 | - |
dc.identifier.scopusid | 2-s2.0-85088583601 | - |
dc.type.rims | ART | - |
dc.citation.volume | 584 | - |
dc.citation.issue | 7821 | - |
dc.citation.beginningpage | 463 | - |
dc.citation.endingpage | 469 | - |
dc.citation.publicationname | NATURE | - |
dc.identifier.doi | 10.1038/s41586-020-2588-y | - |
dc.contributor.localauthor | Oh, Ji Eun | - |
dc.contributor.nonIdAuthor | Lucas, Carolina | - |
dc.contributor.nonIdAuthor | Wong, Patrick | - |
dc.contributor.nonIdAuthor | Klein, Jon | - |
dc.contributor.nonIdAuthor | Castro, Tiago B. R. | - |
dc.contributor.nonIdAuthor | Silva, Julio | - |
dc.contributor.nonIdAuthor | Sundaram, Maria | - |
dc.contributor.nonIdAuthor | Ellingson, Mallory K. | - |
dc.contributor.nonIdAuthor | Mao, Tianyang | - |
dc.contributor.nonIdAuthor | Israelow, Benjamin | - |
dc.contributor.nonIdAuthor | Takahashi, Takehiro | - |
dc.contributor.nonIdAuthor | Tokuyama, Maria | - |
dc.contributor.nonIdAuthor | Lu, Peiwen | - |
dc.contributor.nonIdAuthor | Venkataraman, Arvind | - |
dc.contributor.nonIdAuthor | Park, Annsea | - |
dc.contributor.nonIdAuthor | Mohanty, Subhasis | - |
dc.contributor.nonIdAuthor | Wang, Haowei | - |
dc.contributor.nonIdAuthor | Wyllie, Anne L. | - |
dc.contributor.nonIdAuthor | Vogels, Chantal B. F. | - |
dc.contributor.nonIdAuthor | Earnest, Rebecca | - |
dc.contributor.nonIdAuthor | Lapidus, Sarah | - |
dc.contributor.nonIdAuthor | Ott, Isabel M. | - |
dc.contributor.nonIdAuthor | Moore, Adam J. | - |
dc.contributor.nonIdAuthor | Muenker, M. Catherine | - |
dc.contributor.nonIdAuthor | Fournier, John B. | - |
dc.contributor.nonIdAuthor | Campbell, Melissa | - |
dc.contributor.nonIdAuthor | Odio, Camila D. | - |
dc.contributor.nonIdAuthor | Casanovas-Massana, Arnau | - |
dc.contributor.nonIdAuthor | Herbst, Roy | - |
dc.contributor.nonIdAuthor | Shaw, Albert C. | - |
dc.contributor.nonIdAuthor | Medzhitov, Ruslan | - |
dc.contributor.nonIdAuthor | Schulz, Wade L. | - |
dc.contributor.nonIdAuthor | Grubaugh, Nathan D. | - |
dc.contributor.nonIdAuthor | Dela Cruz, Charles | - |
dc.contributor.nonIdAuthor | Farhadian, Shelli | - |
dc.contributor.nonIdAuthor | Ko, Albert I. | - |
dc.contributor.nonIdAuthor | Omer, Saad B. | - |
dc.contributor.nonIdAuthor | Iwasaki, Akiko | - |
dc.contributor.nonIdAuthor | Obaid, Abeer | - |
dc.contributor.nonIdAuthor | Lu-Culligan, Alice | - |
dc.contributor.nonIdAuthor | Nelson, Allison | - |
dc.contributor.nonIdAuthor | Brito, Anderson | - |
dc.contributor.nonIdAuthor | Nunez, Angela | - |
dc.contributor.nonIdAuthor | Martin, Anjelica | - |
dc.contributor.nonIdAuthor | Watkins, Annie | - |
dc.contributor.nonIdAuthor | Geng, Bertie | - |
dc.contributor.nonIdAuthor | Kalinich, Chaney | - |
dc.contributor.nonIdAuthor | Harden, Christina | - |
dc.contributor.nonIdAuthor | Todeasa, Codruta | - |
dc.contributor.nonIdAuthor | Jensen, Cole | - |
dc.contributor.nonIdAuthor | Kim, Daniel | - |
dc.contributor.nonIdAuthor | McDonald, David | - |
dc.contributor.nonIdAuthor | Shepard, Denise | - |
dc.contributor.nonIdAuthor | Courchaine, Edward | - |
dc.contributor.nonIdAuthor | White, Elizabeth B. | - |
dc.contributor.nonIdAuthor | Song, Eric | - |
dc.contributor.nonIdAuthor | Silva, Erin | - |
dc.contributor.nonIdAuthor | Kudo, Eriko | - |
dc.contributor.nonIdAuthor | DeIuliis, Giuseppe | - |
dc.contributor.nonIdAuthor | Rahming, Harold | - |
dc.contributor.nonIdAuthor | Park, Hong-Jai | - |
dc.contributor.nonIdAuthor | Matos, Irene | - |
dc.contributor.nonIdAuthor | Nouws, Jessica | - |
dc.contributor.nonIdAuthor | Valdez, Jordan | - |
dc.contributor.nonIdAuthor | Fauver, Joseph | - |
dc.contributor.nonIdAuthor | Lim, Joseph | - |
dc.contributor.nonIdAuthor | Rose, Kadi-Ann | - |
dc.contributor.nonIdAuthor | Anastasio, Kelly | - |
dc.contributor.nonIdAuthor | Brower, Kristina | - |
dc.contributor.nonIdAuthor | Glick, Laura | - |
dc.contributor.nonIdAuthor | Sharma, Lokesh | - |
dc.contributor.nonIdAuthor | Sewanan, Lorenzo | - |
dc.contributor.nonIdAuthor | Knaggs, Lynda | - |
dc.contributor.nonIdAuthor | Minasyan, Maksym | - |
dc.contributor.nonIdAuthor | Batsu, Maria | - |
dc.contributor.nonIdAuthor | Petrone, Mary | - |
dc.contributor.nonIdAuthor | Kuang, Maxine | - |
dc.contributor.nonIdAuthor | Nakahata, Maura | - |
dc.contributor.nonIdAuthor | Campbell, Melissa | - |
dc.contributor.nonIdAuthor | Linehan, Melissa | - |
dc.contributor.nonIdAuthor | Askenase, Michael H. | - |
dc.contributor.nonIdAuthor | Simonov, Michael | - |
dc.contributor.nonIdAuthor | Smolgovsky, Mikhail | - |
dc.contributor.nonIdAuthor | Sonnert, Nicole | - |
dc.contributor.nonIdAuthor | Naushad, Nida | - |
dc.contributor.nonIdAuthor | Vijayakumar, Pavithra | - |
dc.contributor.nonIdAuthor | Martinello, Rick | - |
dc.contributor.nonIdAuthor | Datta, Rupak | - |
dc.contributor.nonIdAuthor | Handoko, Ryan | - |
dc.contributor.nonIdAuthor | Bermejo, Santos | - |
dc.contributor.nonIdAuthor | Prophet, Sarah | - |
dc.contributor.nonIdAuthor | Bickerton, Sean | - |
dc.contributor.nonIdAuthor | Velazquez, Sofia | - |
dc.contributor.nonIdAuthor | Alpert, Tara | - |
dc.contributor.nonIdAuthor | Rice, Tyler | - |
dc.contributor.nonIdAuthor | Khoury-Hanold, William | - |
dc.contributor.nonIdAuthor | Peng, Xiaohua | - |
dc.contributor.nonIdAuthor | Yang, Yexin | - |
dc.contributor.nonIdAuthor | Cao, Yiyun | - |
dc.contributor.nonIdAuthor | Strong, Yvette | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | INNATE | - |
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