DC Field | Value | Language |
---|---|---|
dc.contributor.author | Adam, Rene C. | ko |
dc.contributor.author | Yang, Hanseul | ko |
dc.contributor.author | Ge, Yejing | ko |
dc.contributor.author | Infarinato, Nicole R. | ko |
dc.contributor.author | Gur-Cohen, Shiri | ko |
dc.contributor.author | Miao, Yuxuan | ko |
dc.contributor.author | Wang, Ping | ko |
dc.contributor.author | Zhao, Yilin | ko |
dc.contributor.author | Lu, Catherine P. | ko |
dc.contributor.author | Kim, Jeong E. | ko |
dc.contributor.author | Ko, Joo Y. | ko |
dc.contributor.author | Paik, Seung S. | ko |
dc.contributor.author | Gronostajski, Richard M. | ko |
dc.contributor.author | Kim, Jaehwan | ko |
dc.contributor.author | Krueger, James G. | ko |
dc.contributor.author | Zheng, Deyou | ko |
dc.contributor.author | Fuchs, Elaine | ko |
dc.date.accessioned | 2020-11-17T02:55:05Z | - |
dc.date.available | 2020-11-17T02:55:05Z | - |
dc.date.created | 2020-11-17 | - |
dc.date.created | 2020-11-17 | - |
dc.date.created | 2020-11-17 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.citation | NATURE CELL BIOLOGY, v.22, no.6, pp.640 - + | - |
dc.identifier.issn | 1465-7392 | - |
dc.identifier.uri | http://hdl.handle.net/10203/277326 | - |
dc.description.abstract | Adam, Yang et al. show that the transcription factors NFIB and NFIX promote stemness by establishing chromatin accessibility and regulating the super-enhancers that govern bulge stem cell identity. Tissue homeostasis and regeneration rely on resident stem cells (SCs), whose behaviour is regulated through niche-dependent crosstalk. The mechanisms underlying SC identity are still unfolding. Here, using spatiotemporal gene ablation in murine hair follicles, we uncover a critical role for the transcription factors (TFs) nuclear factor IB (NFIB) and IX (NFIX) in maintaining SC identity. Without NFI TFs, SCs lose their hair-regenerating capability, and produce skin bearing striking resemblance to irreversible human alopecia, which also displays reduced NFIs. Through single-cell transcriptomics, ATAC-Seq and ChIP-Seq profiling, we expose a key role for NFIB and NFIX in governing super-enhancer maintenance of the key hair follicle SC-specific TF genes. When NFIB and NFIX are genetically removed, the stemness epigenetic landscape is lost. Super-enhancers driving SC identity are decommissioned, while unwanted lineages are de-repressed ectopically. Together, our findings expose NFIB and NFIX as crucial rheostats of tissue homeostasis, functioning to safeguard the SC epigenome from a breach in lineage confinement that otherwise triggers irreversible tissue degeneration. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices | - |
dc.type | Article | - |
dc.identifier.wosid | 000531794000004 | - |
dc.identifier.scopusid | 2-s2.0-85084450041 | - |
dc.type.rims | ART | - |
dc.citation.volume | 22 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 640 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | NATURE CELL BIOLOGY | - |
dc.identifier.doi | 10.1038/s41556-020-0513-0 | - |
dc.contributor.localauthor | Yang, Hanseul | - |
dc.contributor.nonIdAuthor | Adam, Rene C. | - |
dc.contributor.nonIdAuthor | Ge, Yejing | - |
dc.contributor.nonIdAuthor | Infarinato, Nicole R. | - |
dc.contributor.nonIdAuthor | Gur-Cohen, Shiri | - |
dc.contributor.nonIdAuthor | Miao, Yuxuan | - |
dc.contributor.nonIdAuthor | Wang, Ping | - |
dc.contributor.nonIdAuthor | Zhao, Yilin | - |
dc.contributor.nonIdAuthor | Lu, Catherine P. | - |
dc.contributor.nonIdAuthor | Kim, Jeong E. | - |
dc.contributor.nonIdAuthor | Ko, Joo Y. | - |
dc.contributor.nonIdAuthor | Paik, Seung S. | - |
dc.contributor.nonIdAuthor | Gronostajski, Richard M. | - |
dc.contributor.nonIdAuthor | Kim, Jaehwan | - |
dc.contributor.nonIdAuthor | Krueger, James G. | - |
dc.contributor.nonIdAuthor | Zheng, Deyou | - |
dc.contributor.nonIdAuthor | Fuchs, Elaine | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HAIR FOLLICLE | - |
dc.subject.keywordPlus | NICHE | - |
dc.subject.keywordPlus | QUIESCENCE | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | SEQ | - |
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