Functional characterization of the trans-synaptic adhesion between NGL-3 and LAR at excitatory synapses흥분성 시냅스에서 NGL-3와 LAR 결합과 그 기능에 대한 연구

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dc.contributor.advisorKim, Eun-Joon-
dc.contributor.advisor김은준-
dc.contributor.authorWoo, Joo-Yeon-
dc.contributor.author우주연-
dc.date.accessioned2011-12-12T07:56:15Z-
dc.date.available2011-12-12T07:56:15Z-
dc.date.issued2010-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=455359&flag=dissertation-
dc.identifier.urihttp://hdl.handle.net/10203/27708-
dc.description학위논문(박사) - 한국과학기술원 : 생명과학과, 2010.08, [ viii, 84 p. ]-
dc.description.abstractSynaptic cell adhesion molecules regulate multiple steps of synapse formation and maturation. The great diversity of neuronal synapses predicts the presence of a large number of adhesion molecules that control synapse formation through trans-synaptic and heterophilic adhesion. I identify a novel trans-synaptic interaction between NGL-3, a PSD-95-interacting postsynaptic adhesion molecule, and LAR, a receptor protein tyrosine phosphatase. The leucine-rich repeat (LRR) domain of NGL-3, containing nine LRRs, interacts with the first two fibronectin III (FNIII) domains of LAR to induce bidirectional synapse formation. Moreover, Gln 96 in the first LRR motif of NGL-3 is critical for LAR binding and induction of presynaptic differentiation. Neuronal overexpression of NGL-3 increases presynaptic contacts on dendrites of transfected neurons. Direct aggregation of NGL-3 on dendrites induces coclustering of excitatory postsynaptic proteins. Knockdown of NGL-3 reduces the number of excitatory synapses, but not inhibitory synapses. These results suggest that trans-interaction between NGL-3 and LAR is involved in excitatory synaptic differentiation.eng
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectadhesion-
dc.subjectsynapse-
dc.subjectLAR-
dc.subjectNGL-
dc.subjectsynaptogenesis-
dc.subject시냅스형성-
dc.subject접착-
dc.subject시냅스-
dc.subject-
dc.subject엔지엘-
dc.titleFunctional characterization of the trans-synaptic adhesion between NGL-3 and LAR at excitatory synapses-
dc.title.alternative흥분성 시냅스에서 NGL-3와 LAR 결합과 그 기능에 대한 연구-
dc.typeThesis(Ph.D)-
dc.identifier.CNRN455359/325007 -
dc.description.department한국과학기술원 : 생명과학과, -
dc.identifier.uid020057360-
dc.contributor.localauthorKim, Eun-Joon-
dc.contributor.localauthor김은준-
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