DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Eun-Joon | - |
dc.contributor.advisor | 김은준 | - |
dc.contributor.author | Woo, Joo-Yeon | - |
dc.contributor.author | 우주연 | - |
dc.date.accessioned | 2011-12-12T07:56:15Z | - |
dc.date.available | 2011-12-12T07:56:15Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=455359&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/27708 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2010.08, [ viii, 84 p. ] | - |
dc.description.abstract | Synaptic cell adhesion molecules regulate multiple steps of synapse formation and maturation. The great diversity of neuronal synapses predicts the presence of a large number of adhesion molecules that control synapse formation through trans-synaptic and heterophilic adhesion. I identify a novel trans-synaptic interaction between NGL-3, a PSD-95-interacting postsynaptic adhesion molecule, and LAR, a receptor protein tyrosine phosphatase. The leucine-rich repeat (LRR) domain of NGL-3, containing nine LRRs, interacts with the first two fibronectin III (FNIII) domains of LAR to induce bidirectional synapse formation. Moreover, Gln 96 in the first LRR motif of NGL-3 is critical for LAR binding and induction of presynaptic differentiation. Neuronal overexpression of NGL-3 increases presynaptic contacts on dendrites of transfected neurons. Direct aggregation of NGL-3 on dendrites induces coclustering of excitatory postsynaptic proteins. Knockdown of NGL-3 reduces the number of excitatory synapses, but not inhibitory synapses. These results suggest that trans-interaction between NGL-3 and LAR is involved in excitatory synaptic differentiation. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | adhesion | - |
dc.subject | synapse | - |
dc.subject | LAR | - |
dc.subject | NGL | - |
dc.subject | synaptogenesis | - |
dc.subject | 시냅스형성 | - |
dc.subject | 접착 | - |
dc.subject | 시냅스 | - |
dc.subject | 라 | - |
dc.subject | 엔지엘 | - |
dc.title | Functional characterization of the trans-synaptic adhesion between NGL-3 and LAR at excitatory synapses | - |
dc.title.alternative | 흥분성 시냅스에서 NGL-3와 LAR 결합과 그 기능에 대한 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 455359/325007 | - |
dc.description.department | 한국과학기술원 : 생명과학과, | - |
dc.identifier.uid | 020057360 | - |
dc.contributor.localauthor | Kim, Eun-Joon | - |
dc.contributor.localauthor | 김은준 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.