DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seungwon | ko |
dc.contributor.author | Kim, Hyekang | ko |
dc.contributor.author | You, Gihoon | ko |
dc.contributor.author | Kim, Young-Min | ko |
dc.contributor.author | Lee, Seunghun | ko |
dc.contributor.author | Viet-Hoan Le | ko |
dc.contributor.author | Kwon, Ohseop | ko |
dc.contributor.author | Im, Sin-Hyeog | ko |
dc.contributor.author | Kim, You-Me | ko |
dc.contributor.author | Kim, Kwang Soon | ko |
dc.contributor.author | Sung, Young Chul | ko |
dc.contributor.author | Kim, Ki Hean | ko |
dc.contributor.author | Surh, Charles D. | ko |
dc.contributor.author | Park, Yunji | ko |
dc.contributor.author | Lee, Seung-Woo | ko |
dc.date.accessioned | 2020-11-02T02:55:07Z | - |
dc.date.available | 2020-11-02T02:55:07Z | - |
dc.date.created | 2020-09-15 | - |
dc.date.created | 2020-09-15 | - |
dc.date.created | 2020-09-15 | - |
dc.date.created | 2020-09-15 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.citation | BLOOD, v.134, no.16, pp.1312 - 1322 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | http://hdl.handle.net/10203/277050 | - |
dc.description.abstract | The microbiota regulate hematopoiesis in the bone marrow (BM); however, the detailed mechanisms remain largely unknown. In this study, we explored how microbiota-derived molecules (MDMs) were transferred to the BM and sensed by the local immune cells to control hematopoiesis under steady-state conditions. We reveal that MDMs, including bacterial DNA (bDNA), reach the BM via systemic blood circulation and are captured by CX3CR1(+) mononuclear cells (MNCs). CX3CR1(+) MNCs sense MDMs via endolysosomal Toll-like receptors (TLRs) to produce inflammatory cytokines, which control the basal expansion of hematopoietic progenitors, but not hematopoietic stem cells, and their differentiation potential toward myeloid lineages. CX3CR1(+) MNCs colocate with hematopoietic progenitors at the perivascular region, and the depletion of CX3CR1(+) MNCs impedes bDNA influx into the BM. Moreover, the abrogation of TLR pathways in CX3CR1(+) MNCs abolished the microbiota effect on hematopoiesis. These studies demonstrate that systemic MDMs control BM hematopoiesis by producing CX3CR1(+) MNC-mediated cytokines in the steady-state. | - |
dc.language | English | - |
dc.publisher | AMER SOC HEMATOLOGY | - |
dc.title | Bone marrow CX3CR1(+) mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000493982900008 | - |
dc.identifier.scopusid | 2-s2.0-85074439134 | - |
dc.type.rims | ART | - |
dc.citation.volume | 134 | - |
dc.citation.issue | 16 | - |
dc.citation.beginningpage | 1312 | - |
dc.citation.endingpage | 1322 | - |
dc.citation.publicationname | BLOOD | - |
dc.identifier.doi | 10.1182/blood.2019000495 | - |
dc.contributor.localauthor | Kim, You-Me | - |
dc.contributor.nonIdAuthor | Lee, Seungwon | - |
dc.contributor.nonIdAuthor | Kim, Hyekang | - |
dc.contributor.nonIdAuthor | You, Gihoon | - |
dc.contributor.nonIdAuthor | Kim, Young-Min | - |
dc.contributor.nonIdAuthor | Lee, Seunghun | - |
dc.contributor.nonIdAuthor | Viet-Hoan Le | - |
dc.contributor.nonIdAuthor | Kwon, Ohseop | - |
dc.contributor.nonIdAuthor | Im, Sin-Hyeog | - |
dc.contributor.nonIdAuthor | Kim, Kwang Soon | - |
dc.contributor.nonIdAuthor | Sung, Young Chul | - |
dc.contributor.nonIdAuthor | Kim, Ki Hean | - |
dc.contributor.nonIdAuthor | Surh, Charles D. | - |
dc.contributor.nonIdAuthor | Park, Yunji | - |
dc.contributor.nonIdAuthor | Lee, Seung-Woo | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | GUT MICROBIOTA | - |
dc.subject.keywordPlus | INTESTINAL MACROPHAGES | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | IMMUNITY | - |
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