DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jeong Seok | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2020-10-13T08:55:23Z | - |
dc.date.available | 2020-10-13T08:55:23Z | - |
dc.date.created | 2020-08-31 | - |
dc.date.created | 2020-08-31 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.citation | NATURE REVIEWS IMMUNOLOGY, v.20, no.10, pp.585 - 586 | - |
dc.identifier.issn | 1474-1733 | - |
dc.identifier.uri | http://hdl.handle.net/10203/276537 | - |
dc.description.abstract | In this Comment, Jeong Seok Lee and Eui-Cheol Shin discuss contradictory results regarding the downregulation or upregulation of type I interferon responses in patients with COVID-19 and the implications for therapies that target this pathway. Despite early reports to the contrary, there is increasing evidence that patients with severe COVID-19 have a robust type I interferon response, which contrasts with the delayed, possibly suppressed, interferon response seen early in infection. A robust type I interferon response could exacerbate hyperinflammation in the progression to severe COVID-19 through diverse mechanisms. Further understanding of the roles of type I interferon at different stages of infection and in patients with mild versus severe COVID-19 will provide insights for the therapeutic use of interferon administration or JAK inhibitors in patients with COVID-19. | - |
dc.language | English | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | The type I interferon response in COVID-19: implications for treatment | - |
dc.type | Article | - |
dc.identifier.wosid | 000559368200002 | - |
dc.identifier.scopusid | 2-s2.0-85089312367 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 585 | - |
dc.citation.endingpage | 586 | - |
dc.citation.publicationname | NATURE REVIEWS IMMUNOLOGY | - |
dc.identifier.doi | 10.1038/s41577-020-00429-3 | - |
dc.contributor.localauthor | Lee, Jeong Seok | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Editorial Material | - |
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