DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Hee-Sung | ko |
dc.contributor.author | Lee, Hee-Yoon | ko |
dc.contributor.author | Yang, Aerin | ko |
dc.contributor.author | Ha, Sura | ko |
dc.date.accessioned | 2020-08-07T01:55:18Z | - |
dc.date.available | 2020-08-07T01:55:18Z | - |
dc.identifier.uri | http://hdl.handle.net/10203/275740 | - |
dc.description.abstract | A method for producing a site-specifically modified protein based on new carbon-carbon bond formation is disclosed, including the following three steps (marking, activation, and coupling steps): (a) marking of the modification site by incorporating a specific amino acid into a selected position of a target protein; (b) activation of the marked site; and (c) coupling of various post-translational modification (PTM) moieties or other chemical groups onto the activated site to obtain a site-specifically modified protein. The method for producing a site-specifically modified protein can incorporate desired diverse chemical groups including post-translational modification (PTM) moieties into a designated site in a target protein through a new carbon-carbon bond. Furthermore, the modified protein having a site-specific PTM exhibits the same chemical and functional properties as that of a target protein present in cells. Thus, the present invention is useful for studies of cellular proteins, human diseases including cancers and neurodegenerative diseases, and new drug discovery. | - |
dc.title | METHOD FOR PREPARING SITE-SPECIFICALLY MODIFIED PROTEIN BASED ON NOVEL CARBON-CARBON BOND FORMATION | - |
dc.title.alternative | 새로운 탄소-탄소 결합 기반 위치 특이적으로 변형된 단백질의 제조방법 | - |
dc.type | Patent | - |
dc.type.rims | PAT | - |
dc.contributor.localauthor | Park, Hee-Sung | - |
dc.contributor.localauthor | Lee, Hee-Yoon | - |
dc.contributor.assignee | KAIST | - |
dc.identifier.iprsType | 특허 | - |
dc.identifier.patentApplicationNumber | 15692403 | - |
dc.identifier.patentRegistrationNumber | 10723760 | - |
dc.date.application | 2017-08-31 | - |
dc.date.registration | 2020-07-28 | - |
dc.publisher.country | US | - |
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