DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sung, Pil Soo | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2020-06-22T10:20:12Z | - |
dc.date.available | 2020-06-22T10:20:12Z | - |
dc.date.created | 2020-06-15 | - |
dc.date.issued | 2020-04 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.7 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10203/274774 | - |
dc.description.abstract | When interferons (IFNs) bind to their receptors, they upregulate numerous IFN-stimulated genes (ISGs) with antiviral and immune regulatory activities. Hepatitis C virus (HCV) is a single-stranded, positive-sense RNA virus that affects over 71 million people in the global population. Hepatocytes infected with HCV produce types I and III IFNs. These endogenous IFNs upregulate a set of ISGs that negatively impact the outcome of pegylated IFN-alpha and ribavirin treatments, which were previously used to treat HCV. In addition, the IFNL4 genotype was the primary polymorphism responsible for a suboptimal treatment response to pegylated IFN-alpha and ribavirin. However, recently developed direct-acting antivirals have demonstrated a high rate of sustained virological response without pegylated IFN-alpha. Herein, we review recent studies on types I and III IFN responses in HCV-infected hepatocytes. In particular, we focused on open issues related to IFN responses in the direct-acting antiviral era. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Interferon Response in Hepatitis C Virus-Infected Hepatocytes: Issues to Consider in the Era of Direct-Acting Antivirals | - |
dc.type | Article | - |
dc.identifier.wosid | 000535574200325 | - |
dc.identifier.scopusid | 2-s2.0-85083222581 | - |
dc.type.rims | ART | - |
dc.citation.volume | 21 | - |
dc.citation.issue | 7 | - |
dc.citation.publicationname | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.identifier.doi | 10.3390/ijms21072583 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Sung, Pil Soo | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordAuthor | hepatitis C virus | - |
dc.subject.keywordAuthor | interferon | - |
dc.subject.keywordAuthor | innate immunity | - |
dc.subject.keywordAuthor | direct-acting antivirals | - |
dc.subject.keywordPlus | INNATE IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | STIMULATED GENES | - |
dc.subject.keywordPlus | INTERLEUKIN 28B | - |
dc.subject.keywordPlus | HCV INFECTION | - |
dc.subject.keywordPlus | LAMBDA 4 | - |
dc.subject.keywordPlus | PIAS PROTEINS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | GENOTYPE | - |
dc.subject.keywordPlus | IFN-LAMBDA-4 | - |
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