DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Jeonghun | ko |
dc.contributor.author | Ryu, Jea Sung | ko |
dc.contributor.author | Lee, Moosung | ko |
dc.contributor.author | Jung, Jaehwang | ko |
dc.contributor.author | Han, Seung Yun | ko |
dc.contributor.author | Chung, Hyun Jung | ko |
dc.contributor.author | Park, Yongkeun | ko |
dc.date.accessioned | 2020-04-01T03:20:08Z | - |
dc.date.available | 2020-04-01T03:20:08Z | - |
dc.date.created | 2020-02-23 | - |
dc.date.created | 2020-02-23 | - |
dc.date.created | 2020-02-23 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | BIOMEDICAL OPTICS EXPRESS, v.11, no.3, pp.1257 - 1267 | - |
dc.identifier.issn | 2156-7085 | - |
dc.identifier.uri | http://hdl.handle.net/10203/273750 | - |
dc.description.abstract | Measuring alterations in bacteria upon antibiotic application is important for basic studies in microbiology, drug discovery, clinical diagnosis, and disease treatment. However, imaging and 3D time-lapse response analysis of individual bacteria upon antibiotic application remain largely unexplored mainly due to limitations in imaging techniques. Here, we present a method to systematically investigate the alterations in individual bacteria in 3D and quantitatively analyze the effects of antibiotics. Using optical diffraction tomography, in-situ responses of Escherichia coli and Bacillus subtilis to various concentrations of ampicillin were investigated in a label-free and quantitative manner. The presented method reconstructs the dynamic changes in the 3D refractive-index distributions of living bacteria in response to antibiotics at sub-micrometer spatial resolution. | - |
dc.language | English | - |
dc.publisher | OPTICAL SOC AMER | - |
dc.title | Three-dimensional label-free observation of individual bacteria upon antibiotic treatment using optical diffraction tomography | - |
dc.type | Article | - |
dc.identifier.wosid | 000519518200004 | - |
dc.identifier.scopusid | 2-s2.0-85082298733 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 1257 | - |
dc.citation.endingpage | 1267 | - |
dc.citation.publicationname | BIOMEDICAL OPTICS EXPRESS | - |
dc.identifier.doi | 10.1364/BOE.377740 | - |
dc.contributor.localauthor | Chung, Hyun Jung | - |
dc.contributor.localauthor | Park, Yongkeun | - |
dc.contributor.nonIdAuthor | Han, Seung Yun | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BETA-LACTAM ANTIBIOTICS | - |
dc.subject.keywordPlus | ORGANELLE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | RESOLUTION | - |
dc.subject.keywordPlus | MASS | - |
dc.subject.keywordPlus | LIVE | - |
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