DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyungdeok | ko |
dc.contributor.author | Shin, Wangyong | ko |
dc.contributor.author | Kang, Muwon | ko |
dc.contributor.author | Lee, Suho | ko |
dc.contributor.author | Kim, Doyoun | ko |
dc.contributor.author | Kang, Ryeonghwa | ko |
dc.contributor.author | Jung, Yewon | ko |
dc.contributor.author | Cho, Yisul | ko |
dc.contributor.author | Yang, Esther | ko |
dc.contributor.author | Kim, Hyun | ko |
dc.contributor.author | Bae, Yong Chul | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2020-03-31T09:20:19Z | - |
dc.date.available | 2020-03-31T09:20:19Z | - |
dc.date.created | 2020-03-30 | - |
dc.date.created | 2020-03-30 | - |
dc.date.created | 2020-03-30 | - |
dc.date.created | 2020-03-30 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | ELIFE, v.9 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/10203/273746 | - |
dc.description.abstract | Synaptic adhesion molecules regulate synapse development and function. However, whether and how presynaptic adhesion molecules regulate postsynaptic NMDAR function remains largely unclear. Presynaptic LAR family receptor tyrosine phosphatases (LAR-RPTPs) regulate synapse development through mechanisms that include trans-synaptic adhesion; however, whether they regulate postsynaptic receptor functions remains unknown. Here we report that presynaptic PTP sigma, a LAR-RPTP, enhances postsynaptic NMDA receptor (NMDAR) currents and NMDAR-dependent synaptic plasticity in the hippocampus. This regulation does not involve trans-synaptic adhesions of PTP sigma, suggesting that the cytoplasmic domains of PTP sigma, known to have tyrosine phosphatase activity and mediate protein-protein interactions, are important. In line with this, phosphotyrosine levels of presynaptic proteins, including neurexin-1, are strongly increased in PTP sigma-mutant mice. Behaviorally, PTP sigma-dependent NMDAR regulation is important for social and reward-related novelty recognition. These results suggest that presynaptic PTP sigma regulates postsynaptic NMDAR function through trans-synaptic and direct adhesion-independent mechanisms and novelty recognition in social and reward contexts. | - |
dc.language | English | - |
dc.publisher | ELIFE SCIENCES PUBLICATIONS LTD | - |
dc.title | Presynaptic PTP sigma regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms | - |
dc.type | Article | - |
dc.identifier.wosid | 000519954300001 | - |
dc.identifier.scopusid | 2-s2.0-85082096160 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.publicationname | ELIFE | - |
dc.identifier.doi | 10.7554/eLife.54224 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Lee, Suho | - |
dc.contributor.nonIdAuthor | Kim, Doyoun | - |
dc.contributor.nonIdAuthor | Jung, Yewon | - |
dc.contributor.nonIdAuthor | Cho, Yisul | - |
dc.contributor.nonIdAuthor | Yang, Esther | - |
dc.contributor.nonIdAuthor | Kim, Hyun | - |
dc.contributor.nonIdAuthor | Bae, Yong Chul | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PROTEIN-TYROSINE-PHOSPHATASE | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | ANTERIOR CINGULATE CORTEX | - |
dc.subject.keywordPlus | HIPPOCAMPAL CA2 REGION | - |
dc.subject.keywordPlus | MICE LACKING | - |
dc.subject.keywordPlus | TRANSSYNAPTIC ADHESION | - |
dc.subject.keywordPlus | SYNAPSE DEVELOPMENT | - |
dc.subject.keywordPlus | NEURONAL CIRCUITS | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | NEURAL CIRCUITS | - |
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