DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyunki | ko |
dc.contributor.author | Yoon, Byoung-Ha | ko |
dc.contributor.author | Oh, Chang-Myung | ko |
dc.contributor.author | Lee, Joonyub | ko |
dc.contributor.author | Lee, Kanghoon | ko |
dc.contributor.author | Song, Heein | ko |
dc.contributor.author | Kim, Eunha | ko |
dc.contributor.author | Yi, Kijong | ko |
dc.contributor.author | Kim, Mi-Young | ko |
dc.contributor.author | Kim, Hyeongseok | ko |
dc.contributor.author | Kim, Yong Kyung | ko |
dc.contributor.author | Seo, Eun-Hye | ko |
dc.contributor.author | Heo, Haejeong | ko |
dc.contributor.author | Kim, Hee-Jin | ko |
dc.contributor.author | Lee, Junguee | ko |
dc.contributor.author | Suh, Jae Myoung | ko |
dc.contributor.author | Koo, Seung-Hoi | ko |
dc.contributor.author | Seong, Je Kyung | ko |
dc.contributor.author | Kim, Seyun | ko |
dc.contributor.author | Ju, Young Seok | ko |
dc.contributor.author | Shong, Minho | ko |
dc.contributor.author | Kim, Mirang | ko |
dc.contributor.author | Kim, Hail | ko |
dc.date.accessioned | 2020-03-19T01:23:21Z | - |
dc.date.available | 2020-03-19T01:23:21Z | - |
dc.date.created | 2020-03-16 | - |
dc.date.created | 2020-03-16 | - |
dc.date.created | 2020-03-16 | - |
dc.date.created | 2020-03-16 | - |
dc.date.created | 2020-03-16 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | DIABETES, v.69, no.3, pp.355 - 368 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | http://hdl.handle.net/10203/272354 | - |
dc.description.abstract | Loss of functional beta-cell mass is an essential feature of type 2 diabetes, and maintaining mature beta-cell identity is important for preserving a functional beta-cell mass. However, it is unclear how beta-cells achieve and maintain their mature identity. Here we demonstrate a novel function of protein arginine methyltransferase 1 (PRMT1) in maintaining mature beta-cell identity. Prmt1 knockout in fetal and adult beta-cells induced diabetes, which was aggravated by high-fat diet-induced metabolic stress. Deletion of Prmt1 in adult beta-cells resulted in the immediate loss of histone H4 arginine 3 asymmetric dimethylation (H4R3me2a) and the subsequent loss of beta-cell identity. The expression levels of genes involved in mature beta-cell function and identity were robustly downregulated as soon as Prmt1 deletion was induced in adult beta-cells. Chromatin immunoprecipitation sequencing and assay for transposase-accessible chromatin sequencing analyses revealed that PRMT1-dependent H4R3me2a increases chromatin accessibility at the binding sites for CCCTC-binding factor (CTCF) and beta-cell transcription factors. In addition, PRMT1-dependent open chromatin regions may show an association with the risk of diabetes in humans. Together, our results indicate that PRMT1 plays an essential role in maintaining beta-cell identity by regulating chromatin accessibility. | - |
dc.language | English | - |
dc.publisher | AMER DIABETES ASSOC | - |
dc.title | PRMT1 Is Required for the Maintenance of Mature β-Cell Identity | - |
dc.type | Article | - |
dc.identifier.wosid | 000515719900010 | - |
dc.identifier.scopusid | 2-s2.0-85081142381 | - |
dc.type.rims | ART | - |
dc.citation.volume | 69 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 355 | - |
dc.citation.endingpage | 368 | - |
dc.citation.publicationname | DIABETES | - |
dc.identifier.doi | 10.2337/db19-0685 | - |
dc.contributor.localauthor | Suh, Jae Myoung | - |
dc.contributor.localauthor | Kim, Seyun | - |
dc.contributor.localauthor | Ju, Young Seok | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.localauthor | Kim, Hail | - |
dc.contributor.nonIdAuthor | Yoon, Byoung-Ha | - |
dc.contributor.nonIdAuthor | Oh, Chang-Myung | - |
dc.contributor.nonIdAuthor | Lee, Joonyub | - |
dc.contributor.nonIdAuthor | Song, Heein | - |
dc.contributor.nonIdAuthor | Kim, Mi-Young | - |
dc.contributor.nonIdAuthor | Kim, Yong Kyung | - |
dc.contributor.nonIdAuthor | Seo, Eun-Hye | - |
dc.contributor.nonIdAuthor | Heo, Haejeong | - |
dc.contributor.nonIdAuthor | Kim, Hee-Jin | - |
dc.contributor.nonIdAuthor | Lee, Junguee | - |
dc.contributor.nonIdAuthor | Koo, Seung-Hoi | - |
dc.contributor.nonIdAuthor | Seong, Je Kyung | - |
dc.contributor.nonIdAuthor | Kim, Mirang | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | INSULIN-SECRETION | - |
dc.subject.keywordPlus | ARGININE METHYLTRANSFERASE | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | CHROMATIN STATE | - |
dc.subject.keywordPlus | HISTONE H4 | - |
dc.subject.keywordPlus | METHYLATION | - |
dc.subject.keywordPlus | PDX1 | - |
dc.subject.keywordPlus | ARCHITECTURE | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | DEDIFFERENTIATION | - |
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