DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Lee, Do-heon | - |
dc.contributor.advisor | 이도헌 | - |
dc.contributor.author | Kim, Jun-Ho | - |
dc.contributor.author | 김준호 | - |
dc.date.accessioned | 2011-12-12T07:29:23Z | - |
dc.date.available | 2011-12-12T07:29:23Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=327263&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/27182 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2009. 8., [ vi, 34 p. ] | - |
dc.description.abstract | Current single SNP based GWAS are insufficient to dissect the origin of the complex diseases. Recent studies apply pathway-based analysis as a new paradigm for GWAS to overcome their limitations, but there still exist unavoidable generation of the false positive noises according to the characteristic of LD block. In this study, we propose the way to eliminate the false noises and provide more reliable method to estimate the altered pathways, through considering functional deleterious SNP effects. Only consider functionally significant SNPs as the candidates of the pathway-based analysis, the resulted pathways reflect truer altered activity than the current approaches. We verify this result quantitatively through the classification, and show that our proposed approach has better classification performance than the conventional methods even though the current application coverage is limited. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | GWAS | - |
dc.subject | SNP | - |
dc.subject | pathway-based GWAS | - |
dc.subject | functional SNP | - |
dc.subject | genome-wide association study | - |
dc.subject | 전유전체 연관성 연구 | - |
dc.subject | 단일염기변이 | - |
dc.subject | 회로 기반 연관성 연구 | - |
dc.subject | GWAS | - |
dc.subject | SNP | - |
dc.subject | pathway-based GWAS | - |
dc.subject | functional SNP | - |
dc.subject | genome-wide association study | - |
dc.subject | 전유전체 연관성 연구 | - |
dc.subject | 단일염기변이 | - |
dc.subject | 회로 기반 연관성 연구 | - |
dc.title | Pathway-based genome-wide association study using functional SNP effects | - |
dc.title.alternative | 단일염기변이의 기능적 요소를 고려한 회로 기반 전유전체 연관성 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 327263/325007 | - |
dc.description.department | 한국과학기술원 : 바이오및뇌공학과, | - |
dc.identifier.uid | 020083987 | - |
dc.contributor.localauthor | Lee, Do-heon | - |
dc.contributor.localauthor | 이도헌 | - |
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