DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yeseul | ko |
dc.contributor.author | Lee, Hansuek | ko |
dc.date.accessioned | 2019-12-13T07:23:54Z | - |
dc.date.available | 2019-12-13T07:23:54Z | - |
dc.date.created | 2019-11-11 | - |
dc.date.created | 2019-11-11 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.citation | OPTICS EXPRESS, v.27, no.23, pp.34406 - 34416 | - |
dc.identifier.issn | 1094-4087 | - |
dc.identifier.uri | http://hdl.handle.net/10203/268890 | - |
dc.description.abstract | Biosensing based on whispering-gallery mode (WGM) resonators has been continuously studied with great attention due to its excellent sensitivity guaranteeing the label-free detection. However, its practical impact is insignificant to date despite notable achievements in academic research. Here, we demonstrate a novel practical platform of on-chip WGM sensors integrated with microfluidic channels. By placing silicon nanoclusters as a stable active compound in micro-resonators, the sensor chip can be operated with a remote pump and readout, which simplifies the chip integration and connection to the external setup. In addition, silicon nanoclusters having large absorption cross-section over broad wavelength range allow active sensing for the first time with an LED pump in a top-illumination scheme which significantly reduces the complexity and cost of the measurement setup. The nano-slot structure of 25 nm gap width is embedded in the resonator where the target bio-molecules are selectively detected with the sensitivity enhanced by strongly confined mode-field. The sensitivity confirmed by real-time measurements for the streptavidin-biotin complex is 0.012 nm/nM, improved over 20 times larger than the previously reported WGM sensors with remote readout. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement | - |
dc.language | English | - |
dc.publisher | OPTICAL SOC AMER | - |
dc.title | On-chip label-free biosensing based on active whispering gallery mode resonators pumped by a light-emitting diode | - |
dc.type | Article | - |
dc.identifier.wosid | 000495871300126 | - |
dc.identifier.scopusid | 2-s2.0-85075268105 | - |
dc.type.rims | ART | - |
dc.citation.volume | 27 | - |
dc.citation.issue | 23 | - |
dc.citation.beginningpage | 34406 | - |
dc.citation.endingpage | 34416 | - |
dc.citation.publicationname | OPTICS EXPRESS | - |
dc.identifier.doi | 10.1364/OE.27.034405 | - |
dc.contributor.localauthor | Lee, Hansuek | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | SILICON QUANTUM DOTS | - |
dc.subject.keywordPlus | ADSORPTION | - |
dc.subject.keywordPlus | ARRAYS | - |
dc.subject.keywordPlus | SENSOR | - |
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