DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Min Hee | ko |
dc.contributor.author | Lee, Misun | ko |
dc.contributor.author | Nam, Geewoo | ko |
dc.contributor.author | Kim, Mingeun | ko |
dc.contributor.author | Kang, Juhye | ko |
dc.contributor.author | Choi, Byung Jo | ko |
dc.contributor.author | Jeong, Min Seock | ko |
dc.contributor.author | Park, Kang Ho | ko |
dc.contributor.author | Han, Wan Hui | ko |
dc.contributor.author | Tak, Eunyoung | ko |
dc.contributor.author | Kim, Min Sun | ko |
dc.contributor.author | Lee, Juri | ko |
dc.contributor.author | Lin, Yuxi | ko |
dc.contributor.author | Lee, Young-Ho | ko |
dc.contributor.author | Song, Im-Sook | ko |
dc.contributor.author | Choi, Min-Koo | ko |
dc.contributor.author | Lee, Joo-Yong | ko |
dc.contributor.author | Jin, Hee Kyung | ko |
dc.contributor.author | Bae, Jae-sung | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2019-12-13T07:23:40Z | - |
dc.date.available | 2019-12-13T07:23:40Z | - |
dc.date.created | 2019-11-23 | - |
dc.date.created | 2019-11-23 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.116, no.47, pp.23426 - 23436 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/268885 | - |
dc.description.abstract | As a central feature of neuroinflammation, microglial dysfunction has been increasingly considered a causative factor of neurodegeneration implicating an intertwined pathology with amyloidogenic proteins. Herein, we report the smallest synthetic molecule (N,N'-diacetyl-p-phenylenediamine [DAPPD]), simply composed of a benzene ring with 2 acetamide groups at the para position, known to date as a chemical reagent that is able to promote the phagocytic aptitude of microglia and subsequently ameliorate cognitive defects. Based on our mechanistic investigations in vitro and in vivo, 1) the capability of DAPPD to restore microglial phagocytosis is responsible for diminishing the accumulation of amyloid-beta (A beta) species and significantly improving cognitive function in the brains of 2 types of Alzheimer's disease (AD) transgenic mice, and 2) the rectification of microglial function by DAPPD is a result of its ability to suppress the expression of NLRP3 inflammasome-associated proteins through its impact on the NF-kappa B pathway. Overall, our in vitro and in vivo investigations on efficacies andmolecular-level mechanisms demonstrate the ability of DAPPD to regulate microglial function, suppress neuroinflammation, foster cerebral A beta clearance, and attenuate cognitive deficits in AD transgenic mouse models. Discovery of such antineuroinflammatory compounds signifies the potential in discovering effective therapeutic molecules against AD-associated neurodegeneration. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000498683000015 | - |
dc.identifier.scopusid | 2-s2.0-85075247898 | - |
dc.type.rims | ART | - |
dc.citation.volume | 116 | - |
dc.citation.issue | 47 | - |
dc.citation.beginningpage | 23426 | - |
dc.citation.endingpage | 23436 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.1916318116 | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Park, Min Hee | - |
dc.contributor.nonIdAuthor | Lee, Misun | - |
dc.contributor.nonIdAuthor | Nam, Geewoo | - |
dc.contributor.nonIdAuthor | Kim, Mingeun | - |
dc.contributor.nonIdAuthor | Kang, Juhye | - |
dc.contributor.nonIdAuthor | Choi, Byung Jo | - |
dc.contributor.nonIdAuthor | Jeong, Min Seock | - |
dc.contributor.nonIdAuthor | Park, Kang Ho | - |
dc.contributor.nonIdAuthor | Han, Wan Hui | - |
dc.contributor.nonIdAuthor | Tak, Eunyoung | - |
dc.contributor.nonIdAuthor | Kim, Min Sun | - |
dc.contributor.nonIdAuthor | Lee, Juri | - |
dc.contributor.nonIdAuthor | Lin, Yuxi | - |
dc.contributor.nonIdAuthor | Lee, Young-Ho | - |
dc.contributor.nonIdAuthor | Song, Im-Sook | - |
dc.contributor.nonIdAuthor | Choi, Min-Koo | - |
dc.contributor.nonIdAuthor | Lee, Joo-Yong | - |
dc.contributor.nonIdAuthor | Jin, Hee Kyung | - |
dc.contributor.nonIdAuthor | Bae, Jae-sung | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | small molecule | - |
dc.subject.keywordAuthor | antineuroinflammation | - |
dc.subject.keywordAuthor | microglial phagocytosis | - |
dc.subject.keywordAuthor | amyloid-beta clearance | - |
dc.subject.keywordAuthor | cognitive function | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | NLRP3 INFLAMMASOME | - |
dc.subject.keywordPlus | AMYLOID-BETA | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | NEUROINFLAMMATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CLEARANCE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.subject.keywordPlus | CONTRIBUTES | - |
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