Wavelength-encoded laser particles for massively multiplexed cell tagging

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dc.contributor.authorMartino, Nicolako
dc.contributor.authorKwok, Sheldon J. J.ko
dc.contributor.authorLiapis, Andreas C.ko
dc.contributor.authorForward, Sarahko
dc.contributor.authorJang, Hoonko
dc.contributor.authorKim, Hwi-Minko
dc.contributor.authorWu, Sarah J.ko
dc.contributor.authorWu, Jiaminko
dc.contributor.authorDannenberg, Paul H.ko
dc.contributor.authorLee, Yong-Heeko
dc.contributor.authorJang, Sun-Jooko
dc.contributor.authorYun, Seok-Hyunko
dc.date.accessioned2019-10-15T01:20:12Z-
dc.date.available2019-10-15T01:20:12Z-
dc.date.created2019-10-14-
dc.date.created2019-10-14-
dc.date.issued2019-10-
dc.identifier.citationNATURE PHOTONICS, v.13, no.10, pp.720 - +-
dc.identifier.issn1749-4885-
dc.identifier.urihttp://hdl.handle.net/10203/267976-
dc.description.abstractLarge-scale single-cell analyses have become increasingly important given the role of cellular heterogeneity in complex biological systems. However, no techniques at present enable optical imaging of uniquely tagged individual cells. Fluorescence-based approaches can distinguish only a small number of distinct cells or cell groups at a time because of spectral crosstalk between conventional fluorophores. Here we investigate large-scale cell tracking using intracellular laser particles as imaging probes that emit coherent laser light with a characteristic wavelength. Made of silica-coated semiconductor microcavities, these laser particles have single-mode emission over a broad range from 1,170 nm to 1,580 nm with sub-nanometre linewidths, enabling massive spectral multiplexing. We explore the stability and biocompatibility of these probes in vitro and their utility for wavelength-multiplexed cell tagging and imaging. We demonstrate real-time tracking of thousands of individual cells in a three-dimensional tumour model over several days, showing different behavioural phenotypes.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleWavelength-encoded laser particles for massively multiplexed cell tagging-
dc.typeArticle-
dc.identifier.wosid000487333400013-
dc.identifier.scopusid2-s2.0-85070323788-
dc.type.rimsART-
dc.citation.volume13-
dc.citation.issue10-
dc.citation.beginningpage720-
dc.citation.endingpage+-
dc.citation.publicationnameNATURE PHOTONICS-
dc.identifier.doi10.1038/s41566-019-0489-0-
dc.contributor.localauthorLee, Yong-Hee-
dc.contributor.nonIdAuthorMartino, Nicola-
dc.contributor.nonIdAuthorKwok, Sheldon J. J.-
dc.contributor.nonIdAuthorLiapis, Andreas C.-
dc.contributor.nonIdAuthorForward, Sarah-
dc.contributor.nonIdAuthorJang, Hoon-
dc.contributor.nonIdAuthorKim, Hwi-Min-
dc.contributor.nonIdAuthorWu, Sarah J.-
dc.contributor.nonIdAuthorWu, Jiamin-
dc.contributor.nonIdAuthorDannenberg, Paul H.-
dc.contributor.nonIdAuthorJang, Sun-Joo-
dc.contributor.nonIdAuthorYun, Seok-Hyun-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusCOATED GOLD NANOPARTICLES-
dc.subject.keywordPlusCLONAL DYNAMICS-
dc.subject.keywordPlusREVEALS-
dc.subject.keywordPlusMONODISPERSE-
dc.subject.keywordPlusEXPRESSION-
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