Increased frequency of CD4(+)CD57(+) senescent T cells in patients with newly diagnosed acute heart failure: exploring new pathogenic mechanisms with clinical relevance

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dc.contributor.authorYoun, Jong-Chanko
dc.contributor.authorJung, Min Kyungko
dc.contributor.authorYu, Hee Taeko
dc.contributor.authorKwon, Jisooko
dc.contributor.authorKwak, Jeongeunko
dc.contributor.authorPark, Su-Hyungko
dc.contributor.authorKim, In-Cheolko
dc.contributor.authorPark, Myung-Sooko
dc.contributor.authorLee, Sun Kiko
dc.contributor.authorChoi, Suk-Wonko
dc.contributor.authorHan, Seongwooko
dc.contributor.authorRyu, Kyu-Hyungko
dc.contributor.authorKang, Seok-Minko
dc.contributor.authorShin, Eui-Cheolko
dc.date.accessioned2019-10-02T10:21:30Z-
dc.date.available2019-10-02T10:21:30Z-
dc.date.created2019-10-01-
dc.date.created2019-10-01-
dc.date.issued2019-09-
dc.identifier.citationSCIENTIFIC REPORTS, v.9-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10203/267749-
dc.description.abstractRecent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets of T cells contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties of various subsets of T cells and their clinical implications in human HF. Thirty-eight consecutive patients with newly diagnosed acute HF (21 males, mean age 66 +/- 16 years) and 38 healthy control subjects (21 males, mean age 62 +/- 12 years) were enrolled. We found that pro-inflammatory mediators, including CRP, IL-6 and IP-10 and the frequencies of CD57(+) T cells in the CD4(+) T cell population were significantly elevated in patients with acute HF compared to control subjects. A functional analysis of T cells from patients with acute HF revealed that the CD4(+)CD57(+) T cell population exhibited a higher frequency of IFN-gamma-and TNF-alpha-producing cells compared to the CD4(+)CD57(-)T cell population. Furthermore, the frequency of CD4(+)CD57(+) T cells at baseline and its elevation at the six-month follow-up were significantly related with the development of cardiovascular (CV) events, which were defined as CV mortality, cardiac transplantation, or rehospitalization due to HF exacerbation. In conclusion, CD4(+)CD57(+) senescent T cells showed more inflammatory features and polyfunctionality and were associated with clinical outcome in patients with acute HF. More detailed study for senescent T cells might offer new opportunities for the prevention and treatment of human HF.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleIncreased frequency of CD4(+)CD57(+) senescent T cells in patients with newly diagnosed acute heart failure: exploring new pathogenic mechanisms with clinical relevance-
dc.typeArticle-
dc.identifier.wosid000484657300011-
dc.identifier.scopusid2-s2.0-85071983694-
dc.type.rimsART-
dc.citation.volume9-
dc.citation.publicationnameSCIENTIFIC REPORTS-
dc.identifier.doi10.1038/s41598-019-49332-5-
dc.contributor.localauthorPark, Su-Hyung-
dc.contributor.localauthorShin, Eui-Cheol-
dc.contributor.nonIdAuthorYoun, Jong-Chan-
dc.contributor.nonIdAuthorKim, In-Cheol-
dc.contributor.nonIdAuthorPark, Myung-Soo-
dc.contributor.nonIdAuthorLee, Sun Ki-
dc.contributor.nonIdAuthorChoi, Suk-Won-
dc.contributor.nonIdAuthorHan, Seongwoo-
dc.contributor.nonIdAuthorRyu, Kyu-Hyung-
dc.contributor.nonIdAuthorKang, Seok-Min-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordPlusTUMOR-NECROSIS-FACTOR-
dc.subject.keywordPlusIMMUNE-MECHANISMS-
dc.subject.keywordPlusLYMPHOCYTES-
dc.subject.keywordPlusTHERAPY-
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