DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Park, Chan Beum | - |
dc.contributor.advisor | 박찬범 | - |
dc.contributor.author | Kim, Kayoung | - |
dc.date.accessioned | 2019-09-03T02:45:41Z | - |
dc.date.available | 2019-09-03T02:45:41Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=849897&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/266454 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 신소재공학과, 2016.8,[v, 47 p. :] | - |
dc.description.abstract | The abnormal self-assembly of $\beta-amyloid$ ($A\beta$) peptides into $\beta$-sheet-rich amyloid aggregates and subsequent accumulation in the brain are pathological hallmark of Alzheimer’s disease (AD). Various kinds of photo-active inhibitor have been introduced to suppress the $A\beta$ aggregation using light sources | - |
dc.description.abstract | however, their application has been limited due to their incomplete metabolism in human body and poor permeability to blood brain barrier. Recently, there has been a report that the development of micrometer-scale implantable LED module has been successful, which motivated us to develop photoelectrode-based therapy of AD. Herein, we report on visible light-active hematite ($\alpha-Fe_2O_3$)-based photoanode as an inhibitor for suppression of $A\beta$ aggregation. The synthesized hematite photoanode has a suitable band gap (2.1eV) to absorb visible light and showed effective photoelectrocatalytic activity generating reactive oxidative species(ROS) including superoxide ion(O2·-) and hydroxyl radical(OH·). We demonstrated that when applying a bias and LED to the hematite photoanode, it exhibited effective inhibitory effect on $A\beta$ aggregation owing to hole-derived radical, OH·. Modification of hematite photoanode using co-catalyst, Co-Pi, accelerated the production of OH· and inhibitory effect on $A\beta$ aggregation. Moreover, the hematite photoanode is not only biocompatible, but also effective in suppressing $A\beta-induced$ cytotoxicity. This work gives hints to the potential of utilizing the visible light-active hematite photoanode as an inhibitor of $A\beta$ aggregation for treatment of AD in the future. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | 베타 아밀로이드▼a응집현상 억제▼a광전기화학적▼a산화철 광전극▼a하이드록실 라디칼 | - |
dc.title | Photoelectrocatalytic inhibition of amyloid self-assembly by hematite photoanode | - |
dc.title.alternative | 산화철 광전극을 이용한 광전기화학적 아밀로이드 자기조립 억제 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :신소재공학과, | - |
dc.contributor.alternativeauthor | 김가영 | - |
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