DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Park, Chan Beum | - |
dc.contributor.advisor | 박찬범 | - |
dc.contributor.author | Chung, You Jung | - |
dc.date.accessioned | 2019-09-03T02:45:40Z | - |
dc.date.available | 2019-09-03T02:45:40Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=849896&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/266453 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 신소재공학과, 2016.2,[vi, 40 p. :] | - |
dc.description.abstract | Alzheimer’s disease (AD) is a severe neural disease that progressively damages neurons. One of the major strategies for AD treatment is to inhibit the aggregation of $\beta-amyloid$ ($A\beta$) peptides. Here we report that graphitic carbon nitride ($g-C_3N_4$) has a suppressive ability toward $A\beta$ aggregation under light illumination. Under commercial white light emitting diode (LED) light, photo-induced electrons of $g-C_3N_4$ with a 2.6 eV bandgap generated reactive oxygen species (ROS), such as superoxide anion and singlet oxygen | - |
dc.description.abstract | then, ROS blocked further $A\beta$ fibrillation as a way of photo-oxidation, impacting the conformational structure of $A\beta$ peptides. Through metal doping into a $g-C_3N_4$ framework, we further demonstrated that Fe-doped $g-C_3N_4$ showed enhanced optical properties and stronger inhibition on $A\beta$ aggregation than bare $g-C_3N_4$. Both $g-C_3N_4$ and Fe-doped $g-C_3N_4$ had negligible cytotoxicity and exhibited significant reduction in $A\beta-induced$ cell death. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Graphitic carbon nitride▼aalzheimer's disease▼abeta-amyloid▼aaggregation inhibitor▼areactive oxygen species▼aphoto-oxidation | - |
dc.subject | 카본나이트라이드▼a알츠하이머▼a베타아밀로이드▼a응집억제제▼a활성산소 | - |
dc.title | Photo-active $g-C_3N_4$ nanomaterials for light-induced inhibition of $\beta$-amyloid aggregation | - |
dc.title.alternative | 광감응 $g-C_3N_4$ 나노소재를 이용한 베타-아밀로이드 응집 억제 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :신소재공학과, | - |
dc.contributor.alternativeauthor | 정유정 | - |
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