DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Im, Sung Gap | - |
dc.contributor.advisor | 임성갑 | - |
dc.contributor.author | Lee, Min Seok | - |
dc.date.accessioned | 2019-09-03T02:44:15Z | - |
dc.date.available | 2019-09-03T02:44:15Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=734185&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/266374 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2018.2,[iv, 42 p. :] | - |
dc.description.abstract | Since cancer spheroids can mimic the characteristics of in vivo tumor such as cell-cell, cell-ECM interactions and biochemical gradients, it is emerging as a next-generation platform for various applications including high-throughput drug screening. Currently, numerous methods for cancer spheroid culture have been developed. Conventional methods commonly utilize hydrophilic surface, while our research group has developed a hydrophobic polymer surface which can induce more tumorigenic cancer spheroids. On this point, here, we hypothesize that surface wettability has a significant effect on the characteristics of cancer spheroids. Hydrophilic polymer poly hydroxyethyl methacrylate (pHEMA) and hydrophobic polymer poly cyclohexyl methacrylate (pCHMA) were deposited via initiated Chemical Vapor Deposition (iCVD), and the cancer spheroids induced by these two surfaces were characterized from various perspectives. In particular, we explain tumorigenicity and the related mechanism in relation to the inner structure, thereby suggesting the ideal structure of cancer spheroids. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | cancer spheroid▼ainitiated Chemical Vapor Deposition(iCVD)▼aSurface wettability▼aCell interaction▼aSpheroid mechanism | - |
dc.subject | 암세포 스페로이드▼a개시제를 이용한 기상화학증착법▼a표면 젖음성▼a세포간의 상호작용▼a스페로이드 형성 메커니즘 | - |
dc.title | Characterization of cancer spheroids formed on polymer thin film surfaces with different surface wettability | - |
dc.title.alternative | 고분자 박막의 표면 젖음성 조절에 의해 형성된 암세포 스페로이드의 특성 분석에 관한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명화학공학과, | - |
dc.contributor.alternativeauthor | 이민석 | - |
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