Delivery of niacinamide to the skin using microneedle-like particles = 마이크로니들형 파티클을 이용한 나이아신아마이드의 피부 전달

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The word ‘cosmeceutical’ is used to address products that improve the beauty of the user while also having health benefits. However, the skin’s stratum corneum greatly obstructs the delivery of the active ingredients found in cosmeceutical goods to the skin. Chemical peels and microbeads have been employed to overcome the stratum corneum but these methods can cause side effects and are not environmental friendly. On the other hand, microneedles do not encompass the aforementioned dangers but currently they are only available as patches which make them unsuitable to be used with products that are usually applied onto a large area of the skin. Therefore, this study aimed in developing microneedle-like particles (MLP) whose needles would disrupt the skin during the rubbing of the structure onto the skin. A modified approach from conventional micromolding techniques was employed to make the MLPs and experimental results have shown to have the required mechanical strength. Furthermore, the MLP was able to increase the skin permeability of two fluorescent dyes and niacinamide depending on the applied time and the number of MLPs. Cryosectioned porcine slices have also confirmed the ability of MLPs to enhance skin permeability by revealing a deeper penetration of the applied fluorescent dye. Altogether, the results demonstrated the potential of MLPs to be used as safe skin permeability enhancers that can be rubbed all over the skin.
Advisors
Kim, Yeu-Chunresearcher김유천researcher
Description
한국과학기술원 :생명화학공학과,
Publisher
한국과학기술원
Issue Date
2018
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2018.8,[v, 39 p. :]

Keywords

Transdermal drug delivery▼aniacinamide▼amicroneedle▼amicroparticle▼acosmeceutical; 경피 전달▼a나이아신아마이드▼a마이크로니들▼a마이크로파티클▼a코스메슈티컬

URI
http://hdl.handle.net/10203/266306
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=828519&flag=dissertation
Appears in Collection
CBE-Theses_Master(석사논문)
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