Characterization of cell-type specific IRSp53 mutant mice세포 특이적 IRSp53 결손 생쥐의 특성 연구

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dc.contributor.advisorKim, Eunjoon-
dc.contributor.advisor김은준-
dc.contributor.authorKim, Yangsik-
dc.date.accessioned2019-08-25T02:43:08Z-
dc.date.available2019-08-25T02:43:08Z-
dc.date.issued2019-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=868062&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/265084-
dc.description학위논문(박사) - 한국과학기술원 : 의과학대학원, 2019.2,[iii, 107 p. :]-
dc.description.abstractIRSp53 as an actin modulator is critical for growth and maintenance of dendritic spine, and its knockout in mice showed social deficit. Social deficit makes great burden to psychiatric patients such as schizophrenia and autism. But still, it is needed to be investigated its beneath mechanism and effective therapy for social deficit. Here I show telencephalic excitatory neuron specific Emx1-Cre-
dc.description.abstractIRSp53 flox/flox (f/f) conditional knockout (cKO) mice have social deficit. Chemogenetic modulation of LH restores social deficit in Emx1-Cre-
dc.description.abstractIRSp53 f/f cKO mice, butaggravates social deficit in f/f mice. In addition, I measure inhibitory/excitatory (I/E) ratio from optogenetically evoked synaptic transmission on neurons of the ventral tegmental area (VTA). It is presented with increasing I/E ratio with Emx1-Cre-
dc.description.abstractIRSp53 f/f cKO mice and decreasing I/E ratio with f/f mice during chemogenetic modulation, respectively. Furthermore, inhibitory neuron specific chemogenetic modulation in LH makes social behavior increase in both Emx1-Cre-
dc.description.abstractIRSp53 f/f cKO and control mice. This is the first study to utilise the circuit between LH and VTA for rescue of social behavior in disease-model mouse. In addition, this finding has clinical implication to treat social deficit in psychiatric patients.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectIRSp53▼asocial deficit▼amouse model▼aautism▼aschizophrenia▼alateral hypothalamus▼aventral tegmental area▼achemogenetic modulation▼aoptogenetical patch-clamp▼aexcitatory and inhibitory balance-
dc.subjectIRSp53▼a사회성 결핍▼a마우스 모델▼a자폐질환▼a조현병▼a가측 시상하부▼a배측 덮개 부위▼a화학유전학적 조절▼a광유전학적 전기생리학 실험▼a흥분성과 억제성 균형-
dc.titleCharacterization of cell-type specific IRSp53 mutant mice-
dc.title.alternative세포 특이적 IRSp53 결손 생쥐의 특성 연구-
dc.typeThesis(Ph.D)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :의과학대학원,-
dc.contributor.alternativeauthor김양식-
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