Functional lateralization of medial prefrontal circuits in stress and mood disorder = 스트레스와 정동장애에서 내측 전전두엽 신경회로의 기능적 반구분화에 대한 연구

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Medial prefrontal cortex has known to be involved in various high-cognitive functions and emotional responses through prominent connections with other brain areas. In this thesis, we study the function dissection of mPFC in two kinds of behavior; susceptibility to chronic stress and extinction of conditioned fear. In chapter I, the molecular mechanism for functional difference between the left and the right mPFC in stressed mice is demonstrated by microarray analysis and function of connective tissue growth factor in mediating this laterality is elucidated. In chapter II, using optogenetics, neural circuits in infralimblc cortex is divided as presynaptic inputs from BLA and postsynaptic output and the function of each circuit in fear extinction is analyzed.
Advisors
Kim, Daesooresearcher김대수researcher
Description
한국과학기술원 :생명과학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명과학과, 2017.8,[iii, 70 p. :]

Keywords

mPFC▼achronic stress susceptibility▼alaterality▼afear extinction memory▼afreezing regulation; 내측전전두엽▼a스트레스 민감도▼a반구분화▼a공포기억소거▼a공포반응조절

URI
http://hdl.handle.net/10203/264760
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=866927&flag=dissertation
Appears in Collection
BS-Theses_Ph.D.(박사논문)
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