DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwak, Shinae | ko |
dc.contributor.author | Jung, Min Whan | ko |
dc.date.accessioned | 2019-08-21T07:20:39Z | - |
dc.date.available | 2019-08-21T07:20:39Z | - |
dc.date.created | 2019-08-19 | - |
dc.date.created | 2019-08-19 | - |
dc.date.created | 2019-08-19 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.citation | ELIFE, v.8, pp.1 - 16 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/10203/264358 | - |
dc.description.abstract | The striatum is critically involved in value-based decision making. However, it is unclear how striatal direct and indirect pathways work together to make optimal choices in a dynamic and uncertain environment. Here, we examined the effects of selectively inactivating D1 receptor (D1R)- or D2 receptor (D2R)-expressing dorsal striatal neurons (corresponding to direct-and indirect-pathway neurons, respectively) on mouse choice behavior in a reversal task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Inactivation of either D1R- or D2R-expressing striatal neurons impaired performance in both tasks, but the pattern of altered choice behavior differed between the two animal groups. A reinforcement learning model-based analysis indicated that inactivation of D1R- and D2R-expressing striatal neurons selectively impairs value-dependent action selection and value learning, respectively. Our results suggest differential contributions of striatal direct and indirect pathways to two distinct steps in value-based decision making. | - |
dc.language | English | - |
dc.publisher | ELIFE SCIENCES PUBLICATIONS LTD | - |
dc.title | Distinct roles of striatal direct and indirect pathways in value-based decision making | - |
dc.type | Article | - |
dc.identifier.wosid | 000477604100001 | - |
dc.identifier.scopusid | 2-s2.0-85071917179 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.beginningpage | 1 | - |
dc.citation.endingpage | 16 | - |
dc.citation.publicationname | ELIFE | - |
dc.identifier.doi | 10.7554/eLife.46050 | - |
dc.contributor.localauthor | Jung, Min Whan | - |
dc.contributor.nonIdAuthor | Kwak, Shinae | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BASAL GANGLIA | - |
dc.subject.keywordPlus | DORSAL STRIATUM | - |
dc.subject.keywordPlus | DOPAMINE | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | REWARD | - |
dc.subject.keywordPlus | REINFORCEMENT | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | MOVEMENT | - |
dc.subject.keywordPlus | FLEXIBILITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
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