DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyebin | ko |
dc.contributor.author | Cha, Junghwa | ko |
dc.contributor.author | Jang, Minjeong | ko |
dc.contributor.author | Kim, Pilnam | ko |
dc.date.accessioned | 2019-07-23T06:21:23Z | - |
dc.date.available | 2019-07-23T06:21:23Z | - |
dc.date.created | 2019-07-23 | - |
dc.date.created | 2019-07-23 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.citation | BIOMATERIALS SCIENCE, v.7, no.6, pp.2264 - 2271 | - |
dc.identifier.issn | 2047-4830 | - |
dc.identifier.uri | http://hdl.handle.net/10203/263749 | - |
dc.description.abstract | Hyaluronic acid (HA) is found in various tumor tissues, and is considered tumor-associated extracellular matrix (ECM). Within this tumor-associated ECM, stromal cells, especially immune cells, are involved in tumor progression. However, the effects of tumor-associated ECM on the characteristics of immune cells remain unexplored. Therefore, we studied the triggering effect of HA on spontaneous M2-like polarity of monocytes/macrophages using HA-mixed collagen (HA-COL) matrix. In the presence of HA, expression of the HA receptor (CD44) and M2 polarity-related genes was upregulated in human monocytes (THP-1 cells). We confirmed the CD44-mediated activation of STAT3 in THP-1 cells cultured in an HA-rich environment. Furthermore, when we induced the THP-1 cells to differentiate into cells with M1 or M2 polarity within an HA-rich environment, the HA-rich environment influenced the direction of induction. Our findings might improve understanding of the crosstalk between immune cells and tumor-associated ECM, and facilitate development of tumor immunotherapy strategies. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Hyaluronic acid-based extracellular matrix triggers spontaneous M2-like polarity of monocyte/macrophage | - |
dc.type | Article | - |
dc.identifier.wosid | 000474065900003 | - |
dc.identifier.scopusid | 2-s2.0-85066633424 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 2264 | - |
dc.citation.endingpage | 2271 | - |
dc.citation.publicationname | BIOMATERIALS SCIENCE | - |
dc.identifier.doi | 10.1039/c9bm00155g | - |
dc.contributor.localauthor | Kim, Pilnam | - |
dc.contributor.nonIdAuthor | Kim, Hyebin | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TUMOR-ASSOCIATED MACROPHAGES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CD44 | - |
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