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College of Natural Sciences(자연과학대학)Dept. of Chemistry(화학과)CH-Journal Papers(저널논문)

Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(II)–amyloid-b

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dc.contributor.authorYi, Yelimko
dc.contributor.authorHan, Jiyeonko
dc.contributor.authorPark, Min Heeko
dc.contributor.authorPark, Nahyeko
dc.contributor.authorNam, Eunjuko
dc.contributor.authorJin, Hee Kyungko
dc.contributor.authorBae, Jae-Sungko
dc.contributor.authorLim, Mi Heeko
dc.date.accessioned2019-06-10T02:30:02Z-
dc.date.available2019-06-10T02:30:02Z-
dc.date.created2019-05-22-
dc.date.created2019-05-22-
dc.date.issued2019-05-
dc.identifier.citationCHEMICAL COMMUNICATIONS, v.55, no.42, pp.5847 - 5850-
dc.identifier.issn1359-7345-
dc.identifier.urihttp://hdl.handle.net/10203/262492-
dc.description.abstractWe report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(II)bound amyloid-beta [ Zn(II)-A beta], two pathological targets found in the brain affected by Alzheimer's disease. Rational tuning of the hydrophobicity and Zn(II) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(II)-A beta (phen, 1, and 2), or both (3).-
dc.languageEnglish-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleTunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(II)–amyloid-b-
dc.typeArticle-
dc.identifier.wosid000468478100029-
dc.identifier.scopusid2-s2.0-85065985813-
dc.type.rimsART-
dc.citation.volume55-
dc.citation.issue42-
dc.citation.beginningpage5847-
dc.citation.endingpage5850-
dc.citation.publicationnameCHEMICAL COMMUNICATIONS-
dc.identifier.doi10.1039/c9cc01005j-
dc.contributor.localauthorLim, Mi Hee-
dc.contributor.nonIdAuthorYi, Yelim-
dc.contributor.nonIdAuthorHan, Jiyeon-
dc.contributor.nonIdAuthorPark, Min Hee-
dc.contributor.nonIdAuthorPark, Nahye-
dc.contributor.nonIdAuthorNam, Eunju-
dc.contributor.nonIdAuthorJin, Hee Kyung-
dc.contributor.nonIdAuthorBae, Jae-Sung-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusAMYLOID-BETA-PEPTIDE-
dc.subject.keywordPlusA-BETA-
dc.subject.keywordPlusALZHEIMERS-
dc.subject.keywordPlusSPECTROSCOPY-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusSYSTEM-
dc.subject.keywordPlusZINC-
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