DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yi, Yelim | ko |
dc.contributor.author | Han, Jiyeon | ko |
dc.contributor.author | Park, Min Hee | ko |
dc.contributor.author | Park, Nahye | ko |
dc.contributor.author | Nam, Eunju | ko |
dc.contributor.author | Jin, Hee Kyung | ko |
dc.contributor.author | Bae, Jae-Sung | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2019-06-10T02:30:02Z | - |
dc.date.available | 2019-06-10T02:30:02Z | - |
dc.date.created | 2019-05-22 | - |
dc.date.created | 2019-05-22 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.citation | CHEMICAL COMMUNICATIONS, v.55, no.42, pp.5847 - 5850 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | http://hdl.handle.net/10203/262492 | - |
dc.description.abstract | We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(II)bound amyloid-beta [ Zn(II)-A beta], two pathological targets found in the brain affected by Alzheimer's disease. Rational tuning of the hydrophobicity and Zn(II) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(II)-A beta (phen, 1, and 2), or both (3). | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(II)–amyloid-b | - |
dc.type | Article | - |
dc.identifier.wosid | 000468478100029 | - |
dc.identifier.scopusid | 2-s2.0-85065985813 | - |
dc.type.rims | ART | - |
dc.citation.volume | 55 | - |
dc.citation.issue | 42 | - |
dc.citation.beginningpage | 5847 | - |
dc.citation.endingpage | 5850 | - |
dc.citation.publicationname | CHEMICAL COMMUNICATIONS | - |
dc.identifier.doi | 10.1039/c9cc01005j | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Yi, Yelim | - |
dc.contributor.nonIdAuthor | Han, Jiyeon | - |
dc.contributor.nonIdAuthor | Park, Min Hee | - |
dc.contributor.nonIdAuthor | Park, Nahye | - |
dc.contributor.nonIdAuthor | Nam, Eunju | - |
dc.contributor.nonIdAuthor | Jin, Hee Kyung | - |
dc.contributor.nonIdAuthor | Bae, Jae-Sung | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | AMYLOID-BETA-PEPTIDE | - |
dc.subject.keywordPlus | A-BETA | - |
dc.subject.keywordPlus | ALZHEIMERS | - |
dc.subject.keywordPlus | SPECTROSCOPY | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | ZINC | - |
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