DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hang-Rai | ko |
dc.contributor.author | Park, Young Ho | ko |
dc.contributor.author | Jang, Jae-Won | ko |
dc.contributor.author | Park, So Young | ko |
dc.contributor.author | Wang, Min Jeong | ko |
dc.contributor.author | Baek, Min Jae | ko |
dc.contributor.author | Kim, Beom Joon | ko |
dc.contributor.author | Ahn, Soyeon | ko |
dc.contributor.author | Kim, Sang Yun | ko |
dc.date.accessioned | 2019-05-07T02:50:14Z | - |
dc.date.available | 2019-05-07T02:50:14Z | - |
dc.date.created | 2019-04-03 | - |
dc.date.created | 2019-04-03 | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | JOURNAL OF ALZHEIMERS DISEASE, v.55, no.1, pp.137 - 146 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | http://hdl.handle.net/10203/261800 | - |
dc.description.abstract | Background: Although medial temporal atrophy (MTA) is a useful imaging marker of the progression to dementia in mild cognitive impairment (MCI), substantial numbers of MCI patients without MTA still progress to dementia. Objective: We investigated whether visual ratings of posterior atrophy (PA) on magnetic resonance imaging show independent predictive value for the progression to dementia in MCI patients. Methods: This was a retrospective cohort study of elderly patients who visited Seoul National University Bundang Hospital between 2004 and 2012. A total of 148 patients who were initially diagnosed with MCI were followed for up to 3 years (median 22 months) to determine whether they progressed to dementia. We used 4-point and 5-point visual rating scales to assess PA and MTA, respectively. PA and MTA scores were dichotomized into normal (no atrophy) or abnormal (atrophy) in each patient. We performed a Cox regression analysis to examine the hazard ratios (HRs) of PA and MTA for the progression to dementia with adjustment for age, APOE epsilon 4 allele status, and baseline Mini-Mental State Examination score. Results: Among the study population, 47 patients progressed to dementia. Visual assessment of the MRI scans revealed that 67 patients (45.3%) showed PA, whereas 85 patients (57.3%) showed MTA. The HRs with 95% confidence intervals for PA and MTA were 2.516 (1.244-5.091) and 4.238 (1.680-10.687), respectively. The predictive values of visually assessed PA and MTA remained significant, independent of the covariates. Conclusion: Visual assessment of PA has independent predictive value for progression to dementia in MCI patients. | - |
dc.language | English | - |
dc.publisher | IOS PRESS | - |
dc.title | Visual Rating of Posterior Atrophy as a Marker of Progression to Dementia in Mild Cognitive Impairment Patients | - |
dc.type | Article | - |
dc.identifier.wosid | 000387671600012 | - |
dc.identifier.scopusid | 2-s2.0-84994571101 | - |
dc.type.rims | ART | - |
dc.citation.volume | 55 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 137 | - |
dc.citation.endingpage | 146 | - |
dc.citation.publicationname | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.identifier.doi | 10.3233/JAD-160339 | - |
dc.contributor.nonIdAuthor | Park, Young Ho | - |
dc.contributor.nonIdAuthor | Jang, Jae-Won | - |
dc.contributor.nonIdAuthor | Park, So Young | - |
dc.contributor.nonIdAuthor | Wang, Min Jeong | - |
dc.contributor.nonIdAuthor | Baek, Min Jae | - |
dc.contributor.nonIdAuthor | Kim, Beom Joon | - |
dc.contributor.nonIdAuthor | Ahn, Soyeon | - |
dc.contributor.nonIdAuthor | Kim, Sang Yun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Atrophy | - |
dc.subject.keywordAuthor | biomarker | - |
dc.subject.keywordAuthor | disease progression | - |
dc.subject.keywordAuthor | mild cognitive impairment | - |
dc.subject.keywordPlus | VOXEL-BASED MORPHOMETRY | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | CORTICAL THICKNESS | - |
dc.subject.keywordPlus | DEFINED SUBTYPES | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | AD | - |
dc.subject.keywordPlus | HIPPOCAMPAL | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | GUIDELINES | - |
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