DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, JA | ko |
dc.contributor.author | Lim, CS | ko |
dc.contributor.author | Lee, Seung-Hee | ko |
dc.contributor.author | Kim, H | ko |
dc.contributor.author | Nukina, N | ko |
dc.contributor.author | Kaang, BK | ko |
dc.date.accessioned | 2019-04-15T16:32:48Z | - |
dc.date.available | 2019-04-15T16:32:48Z | - |
dc.date.created | 2013-09-13 | - |
dc.date.issued | 2003-04 | - |
dc.identifier.citation | JOURNAL OF NEUROCHEMISTRY, v.85, no.1, pp.160 - 169 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.uri | http://hdl.handle.net/10203/255914 | - |
dc.description.abstract | Huntington's disease (HD) is caused by an expansion of a polyglutamine (polyQ) tract within huntingtin (htt) protein. To examine the cytotoxic effects of polyQ-expanded htt, we overexpressed an enhanced green fluorescent protein (EGFP)-tagged N-terminal fragment of htt with 150 glutamine residues (Nhtt150Q-EGFP) in Aplysia neurons. A combined confocal and electron microscopic study showed that Aplysia neurons expressing Nhtt150Q-EGFP displayed numerous abnormal aggregates (diameter 0.5-5 mum) of filamentous structures, which were formed rapidly (approximately 2 h) but which were sustained for at least 18 days in the cytoplasm. Furthermore, the overexpression of Nhtt150Q-EGFP in sensory cells impaired 5-hydroxytryptamine (5-HT)-induced long-term synaptic facilitation in sensori-motor synapses without affecting basal synaptic strength or short-term facilitation. This study demonstrates the stability of polyQ-based aggregates and their specific effects on long-term synaptic plasticity. | - |
dc.language | English | - |
dc.publisher | BLACKWELL PUBLISHING | - |
dc.subject | EXPANDED POLYGLUTAMINE | - |
dc.subject | CELL-DEATH | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | INTRANUCLEAR INCLUSIONS | - |
dc.subject | GLUTAMINE REPEATS | - |
dc.subject | NEURODEGENERATIVE DISEASES | - |
dc.subject | MEDIATED TRANSCRIPTION | - |
dc.subject | CASPASE ACTIVATION | - |
dc.subject | SENSORY NEURONS | - |
dc.subject | BINDING PROTEIN | - |
dc.title | Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons | - |
dc.type | Article | - |
dc.identifier.wosid | 000181651900017 | - |
dc.type.rims | ART | - |
dc.citation.volume | 85 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 160 | - |
dc.citation.endingpage | 169 | - |
dc.citation.publicationname | JOURNAL OF NEUROCHEMISTRY | - |
dc.identifier.doi | 10.1046/j.1471-4159.2003.01650.x | - |
dc.contributor.localauthor | Lee, Seung-Hee | - |
dc.contributor.nonIdAuthor | Lee, JA | - |
dc.contributor.nonIdAuthor | Lim, CS | - |
dc.contributor.nonIdAuthor | Kim, H | - |
dc.contributor.nonIdAuthor | Nukina, N | - |
dc.contributor.nonIdAuthor | Kaang, BK | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | aggregation | - |
dc.subject.keywordAuthor | Aplysia | - |
dc.subject.keywordAuthor | huntingtin | - |
dc.subject.keywordAuthor | polyglutamine | - |
dc.subject.keywordAuthor | synaptic facilitation | - |
dc.subject.keywordPlus | EXPANDED POLYGLUTAMINE | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | INTRANUCLEAR INCLUSIONS | - |
dc.subject.keywordPlus | GLUTAMINE REPEATS | - |
dc.subject.keywordPlus | NEURODEGENERATIVE DISEASES | - |
dc.subject.keywordPlus | MEDIATED TRANSCRIPTION | - |
dc.subject.keywordPlus | CASPASE ACTIVATION | - |
dc.subject.keywordPlus | SENSORY NEURONS | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
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