DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Mi Hwa | ko |
dc.contributor.author | Kim, Jee Seon | ko |
dc.contributor.author | Lee, Jeong Yu | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.contributor.author | Nam, YoonSung | ko |
dc.date.accessioned | 2019-04-15T15:50:55Z | - |
dc.date.available | 2019-04-15T15:50:55Z | - |
dc.date.created | 2013-09-12 | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | RSC ADVANCES, v.3, no.34, pp.14642 - 14651 | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | http://hdl.handle.net/10203/255305 | - |
dc.description.abstract | The integration of therapeutic and imaging functions in a nanoscale structure is gaining increasing attention to monitor drug and gene delivery in a non-invasive real-time manner. Here we introduce radio-opaque nanoemulsions incorporating paclitaxel and Bcl-2 small interfering RNA (siRNA) for synergistic anti-cancer theranostics. Water-insoluble paclitaxel is readily dissolved in iodinated poppy seed oil (Lipiodol) and emulsified in an aqueous solution using a mixture of PEGylated phospholipids, cholesterols, and linear polyethylenimine grafted with cholesterols. The prepared cationic nanoemulsions were electrostatically complexed with Bcl-2 siRNA for the co-delivery of paclitaxel and siRNA, inducing a dramatically higher level of apoptosis and cytotoxic activity in breast adenocarcinoma compared to individual treatments. The feasibility of the nanoemulsions for bio-imaging applications is preliminarily investigated using micro-computed tomography with a mouse model. This study suggests that the Lipiodol nanoemulsions can be used as a multifunctional nanocarrier platform for the co-delivery of anticancer drugs and siRNA with bio-imaging functionality to efficiently increase the modality of anti-cancer theranostics. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | BREAST-CANCER CELLS | - |
dc.subject | GENE DELIVERY | - |
dc.subject | CONTRAST-MEDIUM | - |
dc.subject | DRUG-THERAPY | - |
dc.subject | CO-DELIVERY | - |
dc.subject | NANOPARTICLES | - |
dc.subject | LIPIODOL | - |
dc.subject | APOPTOSIS | - |
dc.subject | SURVIVAL | - |
dc.subject | CHEMOTHERAPY | - |
dc.title | Radio-opaque theranostic nanoemulsions with synergistic anti-cancer activity of paclitaxel and Bcl-2 siRNA | - |
dc.type | Article | - |
dc.identifier.wosid | 000322737400060 | - |
dc.identifier.scopusid | 2-s2.0-84881422645 | - |
dc.type.rims | ART | - |
dc.citation.volume | 3 | - |
dc.citation.issue | 34 | - |
dc.citation.beginningpage | 14642 | - |
dc.citation.endingpage | 14651 | - |
dc.citation.publicationname | RSC ADVANCES | - |
dc.identifier.doi | 10.1039/c3ra40883c | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.localauthor | Nam, YoonSung | - |
dc.contributor.nonIdAuthor | Oh, Mi Hwa | - |
dc.contributor.nonIdAuthor | Kim, Jee Seon | - |
dc.contributor.nonIdAuthor | Lee, Jeong Yu | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BREAST-CANCER CELLS | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | CONTRAST-MEDIUM | - |
dc.subject.keywordPlus | DRUG-THERAPY | - |
dc.subject.keywordPlus | CO-DELIVERY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | LIPIODOL | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
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