DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jinho | ko |
dc.contributor.author | Park, Seho | ko |
dc.contributor.author | Kim, Sunghyun | ko |
dc.contributor.author | Lee, In-Hyun | ko |
dc.contributor.author | Saw, Phei Er | ko |
dc.contributor.author | Lee, Kwangyeol | ko |
dc.contributor.author | Kim, Yong-Chul | ko |
dc.contributor.author | Kim, Young-Joon | ko |
dc.contributor.author | Farokhzad, Omid C. | ko |
dc.contributor.author | Jeong, Yong Yeon | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.date.accessioned | 2019-04-15T15:50:49Z | - |
dc.date.available | 2019-04-15T15:50:49Z | - |
dc.date.created | 2013-09-26 | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | JOURNAL OF MATERIALS CHEMISTRY , v.1, no.36, pp.4576 - 4583 | - |
dc.identifier.issn | 2050-750X | - |
dc.identifier.uri | http://hdl.handle.net/10203/255302 | - |
dc.description.abstract | Here, we report a nanotheranostic system that enables simultaneous imaging and therapy of HER2-overexpressing tumors. We first screened an aptide-based phage library for HER2-specific peptide ligands, identifying a HER2-specific aptide (APT(HER2)) phage clone. Chemically synthesized APT(HER2) showed high affinity for its target protein (K-d approximate to 89 nM) and specifically bound HER2-overexpressing cells (NIH3T6.7) and tumor tissue slices. Next, we prepared HER2-specific-aptide-conjugated magnetonanoclusters (APT(HER2)-MNCs) by a rehydration method using oleic acid-stabilized superparamagnetic iron oxide nanoparticles (SPIONs) and amphiphilic phospholipids, yielding nanoparticles with a hydrodynamic diameter of 47 +/- 10 nm. The APT(HER2)-MNCs showed higher transverse (r(2)) relaxivity (similar to 180 mM(-1) s(-1)) and greater drug-loading capacity compared to the equivalent isolated SPIONs (similar to 120 mM(-1) s(-1)). When intravenously injected into HER2-overexpressing NIH3T6.7 tumor-bearing mice, APT(HER2)-MNCs substantially accumulated in tumor tissue, enhancing the relative signal by similar to 45% at 3 h post-injection. This allowed us to detect the tumor using magnetic resonance imaging. Furthermore, after docetaxel loading, the drug-loaded APT(HER2)-MNCs remarkably inhibited the growth of HER2-overexpressing tumors (similar to 50% relative to controls) with little apparent toxicity, measured as changes in body weight. Together, these results indicate that APT(HER2)-MNCs show promise as an efficient nanotheranostic system that enables specific cancer imaging as well as targeted therapy. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | IRON-OXIDE NANOPARTICLES | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | POLYMERIC MICELLES | - |
dc.subject | NANOMEDICINE | - |
dc.subject | PEPTIDES | - |
dc.subject | DESIGN | - |
dc.title | HER2-specific aptide conjugated magneto-nanoclusters for potential breast cancer imaging and therapy | - |
dc.type | Article | - |
dc.identifier.wosid | 000323484100005 | - |
dc.identifier.scopusid | 2-s2.0-84883003981 | - |
dc.type.rims | ART | - |
dc.citation.volume | 1 | - |
dc.citation.issue | 36 | - |
dc.citation.beginningpage | 4576 | - |
dc.citation.endingpage | 4583 | - |
dc.citation.publicationname | JOURNAL OF MATERIALS CHEMISTRY | - |
dc.identifier.doi | 10.1039/c3tb20613k | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.nonIdAuthor | Park, Jinho | - |
dc.contributor.nonIdAuthor | Park, Seho | - |
dc.contributor.nonIdAuthor | Kim, Sunghyun | - |
dc.contributor.nonIdAuthor | Lee, In-Hyun | - |
dc.contributor.nonIdAuthor | Saw, Phei Er | - |
dc.contributor.nonIdAuthor | Lee, Kwangyeol | - |
dc.contributor.nonIdAuthor | Kim, Yong-Chul | - |
dc.contributor.nonIdAuthor | Kim, Young-Joon | - |
dc.contributor.nonIdAuthor | Farokhzad, Omid C. | - |
dc.contributor.nonIdAuthor | Jeong, Yong Yeon | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | IRON-OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | POLYMERIC MICELLES | - |
dc.subject.keywordPlus | NANOMEDICINE | - |
dc.subject.keywordPlus | PEPTIDES | - |
dc.subject.keywordPlus | DESIGN | - |
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