DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Minah | ko |
dc.contributor.author | Ku, Sook Hee | ko |
dc.contributor.author | Ryu, Jungki | ko |
dc.contributor.author | Park, Chan Beum | ko |
dc.date.accessioned | 2011-11-08T02:35:24Z | - |
dc.date.available | 2011-11-08T02:35:24Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | JOURNAL OF MATERIALS CHEMISTRY, v.20, no.40, pp.8848 - 8853 | - |
dc.identifier.issn | 0959-9428 | - |
dc.identifier.uri | http://hdl.handle.net/10203/25516 | - |
dc.description.abstract | Hydroxyapatite (HAp)/carbon nanotubes (CNTs) hybrid composite materials are successfully synthesized via a biomineralization process that employs poly(dopamine) (PDA), a synthetic mimic of mussel adhesive proteins. Creating bio-inorganic composites for regenerative medicine requires appropriate fillers to enhance their mechanical robustness; for example, natural bones are composed mainly of HAp supported by collagen fibers. In this regard, many efforts have been made to harness HAp as a bone substitute through its integration with reinforcing fibrous materials such as CNTs. We found that the formation of a PDA ad-layer on the surface of CNTs changed the hydrophobic CNTs to become bioactive. This enabled efficient interaction between the CNTs and mineral ions (e. g., Ca(2+)), which facilitated the mineralization of HAp. CNTs functionalized with PDA (CNT-PDA) highly accelerated the formation of HAp when incubated in a simulated body fluid and exhibited a minimal cytotoxic effect on bone osteoblast cells compared to pristine or carboxylated CNTs. Our results show the potential of CNT-PDA as a scaffold material for bone tissue regeneration and implantation. | - |
dc.description.sponsorship | This study was supported by the institutional grant from KAIST Institute for the NanoCentury (KINC), the National Research Foundation via National Research Laboratory (NRL) (R0A- 2008-000-20041-0) and Converging Research Center (2009- 0082276) Programs. This research was also partially supported by the Fundamental R&D Program for Core Technology of Materials from the Ministry of Knowledge Economy and the BioGreen 21 Program (20070301034038), Republic of Korea. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Royal Soc Chemistry | - |
dc.subject | BIOMEDICAL APPLICATIONS | - |
dc.subject | BONE | - |
dc.subject | COMPOSITES | - |
dc.subject | COATINGS | - |
dc.subject | SYSTEMS | - |
dc.subject | APATITE | - |
dc.title | Mussel-inspired functionalization of carbon nanotubes for hydroxyapatite mineralization | - |
dc.type | Article | - |
dc.identifier.wosid | 000282518200011 | - |
dc.identifier.scopusid | 2-s2.0-77957769711 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.issue | 40 | - |
dc.citation.beginningpage | 8848 | - |
dc.citation.endingpage | 8853 | - |
dc.citation.publicationname | JOURNAL OF MATERIALS CHEMISTRY | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Chan Beum | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BIOMEDICAL APPLICATIONS | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | COMPOSITES | - |
dc.subject.keywordPlus | COATINGS | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | APATITE | - |
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