DC Field | Value | Language |
---|---|---|
dc.contributor.author | Joshi, Nikhil S. | ko |
dc.contributor.author | Cui, Weiguo | ko |
dc.contributor.author | Chandele, Anmol | ko |
dc.contributor.author | Lee, HeungKyu | ko |
dc.contributor.author | Urso, David R. | ko |
dc.contributor.author | Hagman, James | ko |
dc.contributor.author | Gapin, Laurent | ko |
dc.contributor.author | Kaech, Susan M. | ko |
dc.date.accessioned | 2011-11-08T01:48:18Z | - |
dc.date.available | 2011-11-08T01:48:18Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-08 | - |
dc.identifier.citation | IMMUNITY, v.27, no.2, pp.281 - 295 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/25511 | - |
dc.description.abstract | As acute infections resolve, effector CD8(+) T cells differentiate into interleukin-7 receptor(lo) (IL-7R(lo)) short-lived effector cells (SLECs) and IL-7R(hi) memory precursor effector cells (MPECs) capable of generating long-lived memory CD8(+) T cells. By using another SLEC marker, KLRG1, we found that KLRG1(hi) effector cells began appearing early during infection and were committed to downregulating IL-7R. Unlike IL-7R(hi) MPECs, KLRG1(hi) IL-7R(lo) SLECs relied on IL-15, but I L-15 could not sustain their long-term maintenance or homeostatic turnover. The decision between SLEC and MPEC fates was regulated by the amount of inflammatory cytokines (i.e., IL-12) present during T cell priming. According to the amount of inflammation, a gradient of T-bet was created in which high T-bet expression induced SLECs and low expression promoted MPECs. These results elucidate a mechanism by which the innate immune system sets the relative amounts of a lineage-determining transcription factor in activated CD8(+) T cells and, correspondingly, regulates their memory cell potential. | - |
dc.description.sponsorship | The authors would like to thank M. Shlomchik, R. Medzhitov, G. Lyons, G. Tokmoulina, E. Hinson, and the Kaech lab for comments and technical expertise; L. Glimcher for T-bet RV constructs, antibody, and Tbx21/ mice; and E.J. Wherry and L.C. Eisenlohr for rVVhp strains. This work was supported by the Burroughs-Wellcome Fund 1004313 (S.M.K.), NIH RO1 AI 066232-01 (S.M.K.), Edward Mallinckrodt, Jr., Foundation (S.M.K.), NIH T32 A1055403 (N.S.J.), Richard K. Gershon Predoctoral Fellowship (N.S.J.), the Korean Ministry of Science and Technology (H.K.L.), R01 AI057485 (L.G.), and P01 AI22295, R01 AI054661, and R01 AI056322 (to J.H.). | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | CELL PRESS | - |
dc.subject | CUTTING EDGE | - |
dc.subject | SELECTIVE EXPRESSION | - |
dc.subject | PROTECTIVE IMMUNITY | - |
dc.subject | VIRAL-INFECTIONS | - |
dc.subject | IL-7 RECEPTOR | - |
dc.subject | IN-VIVO | - |
dc.subject | ANTIGEN | - |
dc.subject | RESPONSES | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | HOMEOSTASIS | - |
dc.title | Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor | - |
dc.type | Article | - |
dc.identifier.wosid | 000249056300014 | - |
dc.identifier.scopusid | 2-s2.0-34548027000 | - |
dc.type.rims | ART | - |
dc.citation.volume | 27 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 281 | - |
dc.citation.endingpage | 295 | - |
dc.citation.publicationname | IMMUNITY | - |
dc.identifier.doi | 10.1016/j.immuni.2007.07.010 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, HeungKyu | - |
dc.contributor.nonIdAuthor | Joshi, Nikhil S. | - |
dc.contributor.nonIdAuthor | Cui, Weiguo | - |
dc.contributor.nonIdAuthor | Chandele, Anmol | - |
dc.contributor.nonIdAuthor | Urso, David R. | - |
dc.contributor.nonIdAuthor | Hagman, James | - |
dc.contributor.nonIdAuthor | Gapin, Laurent | - |
dc.contributor.nonIdAuthor | Kaech, Susan M. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | CELLIMMUNO | - |
dc.subject.keywordAuthor | MOLIMMUNO | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | SELECTIVE EXPRESSION | - |
dc.subject.keywordPlus | PROTECTIVE IMMUNITY | - |
dc.subject.keywordPlus | VIRAL-INFECTIONS | - |
dc.subject.keywordPlus | IL-7 RECEPTOR | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
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