DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Junho | ko |
dc.contributor.author | Kim, Dachan | ko |
dc.contributor.author | Lim, Jae Seok | ko |
dc.contributor.author | Maeng, Ju Heon | ko |
dc.contributor.author | Son, Hyeonju | ko |
dc.contributor.author | Kang, Hoon-Chul | ko |
dc.contributor.author | Nam, Hojung | ko |
dc.contributor.author | Lee, Jeong Ho | ko |
dc.contributor.author | Kim, Sangwoo | ko |
dc.date.accessioned | 2019-04-15T14:30:39Z | - |
dc.date.available | 2019-04-15T14:30:39Z | - |
dc.date.created | 2019-03-18 | - |
dc.date.created | 2019-03-18 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.10 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/254118 | - |
dc.description.abstract | Accurate genome-wide detection of somatic mutations with low variant allele frequency (VAF, <1%) has proven difficult, for which generalized, scalable methods are lacking. Herein, we describe a new computational method, called RePlow, that we developed to detect low-VAF somatic mutations based on simple, library-level replicates for next-generation sequencing on any platform. Through joint analysis of replicates, RePlow is able to remove prevailing background errors in next-generation sequencing analysis, facilitating remarkable improvement in the detection accuracy for low-VAF somatic mutations (up to similar to 99% reduction in false positives). The method is validated in independent cancer panel and brain tissue sequencing data. Our study suggests a new paradigm with which to exploit an overwhelming abundance of sequencing data for accurate variant detection. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | The use of technical replication for detection of low-level somatic mutations in next-generation sequencing | - |
dc.type | Article | - |
dc.identifier.wosid | 000460402300006 | - |
dc.identifier.scopusid | 2-s2.0-85062551946 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/s41467-019-09026-y | - |
dc.contributor.localauthor | Lee, Jeong Ho | - |
dc.contributor.nonIdAuthor | Kim, Junho | - |
dc.contributor.nonIdAuthor | Kim, Dachan | - |
dc.contributor.nonIdAuthor | Maeng, Ju Heon | - |
dc.contributor.nonIdAuthor | Son, Hyeonju | - |
dc.contributor.nonIdAuthor | Kang, Hoon-Chul | - |
dc.contributor.nonIdAuthor | Nam, Hojung | - |
dc.contributor.nonIdAuthor | Kim, Sangwoo | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | RARE MUTATIONS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | ERRORS | - |
dc.subject.keywordPlus | BRAF | - |
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