DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Hi Eun | ko |
dc.contributor.author | Oh, Ji Eun | ko |
dc.contributor.author | Lee, Heung Kyu | ko |
dc.date.accessioned | 2019-04-03T02:30:49Z | - |
dc.date.available | 2019-04-03T02:30:49Z | - |
dc.date.created | 2019-02-14 | - |
dc.date.created | 2019-02-14 | - |
dc.date.created | 2019-02-14 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.citation | VIRUSES-BASEL, v.11, no.2 | - |
dc.identifier.issn | 1999-4915 | - |
dc.identifier.uri | http://hdl.handle.net/10203/253018 | - |
dc.description.abstract | Dynamin-like GTPase myxovirus resistance protein 1 (Mx1) is an intracellular anti-viral protein following the activation of type I and type III interferon signaling. Mx1 inhibits viral replication by blocking the transcription of viral RNA, and a deficiency in this protein enhances susceptibility to influenza infection. Thus, Mx1 could be another efficient target of anti-influenza therapy. To test our hypothesis, we fused poly-arginine cell-penetrating peptides to the C terminus of Mx1 (Mx1-9R) and examined the anti-viral activity of Mx1-9R in vitro and in vivo. Madin-Darby Canine Kidney epithelial cells internalized the Mx1-9R within 12 h. Pre-exposure Mx1-9R treatment inhibited viral replication and viral RNA expression in infected cells. Further, intranasal administration of Mx1-9R improved the survival of mice infected with the PR8 influenza viral strain. These data support the consideration of Mx1-9R as a novel therapeutic agent against mucosal influenza virus infection. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Cell-Penetrating Mx1 Enhances Anti-Viral Resistance against Mucosal Influenza Viral Infection | - |
dc.type | Article | - |
dc.identifier.wosid | 000460803200019 | - |
dc.identifier.scopusid | 2-s2.0-85060807754 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 2 | - |
dc.citation.publicationname | VIRUSES-BASEL | - |
dc.identifier.doi | 10.3390/v11020109 | - |
dc.contributor.localauthor | Oh, Ji Eun | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Mx1 | - |
dc.subject.keywordAuthor | influenza virus | - |
dc.subject.keywordAuthor | cell-penetrating peptide | - |
dc.subject.keywordAuthor | type I interferon | - |
dc.subject.keywordPlus | IN-VITRO INHIBITION | - |
dc.subject.keywordPlus | GENE PROTECTS MICE | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | TAT PROTEIN | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | PEPTIDE | - |
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