DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, JW | ko |
dc.contributor.author | Kim, K | ko |
dc.contributor.author | Kang, K | ko |
dc.contributor.author | Joe, Cheol O | ko |
dc.date.accessioned | 2011-09-19T01:36:38Z | - |
dc.date.available | 2011-09-19T01:36:38Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2000-03 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.275, no.11, pp.8121 - 8125 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10203/25220 | - |
dc.description.abstract | biochemical role of the C-terminal fragment of poly(ADP-ribose) polymerase (PARP) was investigated in HeLa cells undergoing UV-mediated apoptoisis. During the course of apoptosis, the C-terminal cleavage product of PARP interacted with intact PARP and down-regulated PARP activity by blocking the homodimerization of PARP. The basic leucine zipper motif in the auto-modification domain of the C-terminal fragment of PARP represented the site of association, and Leu(405) was critical to the ability of the basic leucine zipper motif to associate with intact PARP. The expression of the C-terminal fragment of PARP stimulated UV-mediated apoptosis. These results suggest that the C-terminal cleavage product of PARP produced during apoptosis blocks the homodimerization of PARP and inhibits the cellular PARP activity. The inhibition of the cellular PARP activity might prevent cellular NAD(+) depletion and stimulate apoptosis by maintaining the basal cellular energy level required for the completion of apoptosis. | - |
dc.description.sponsorship | This work was supported in part by a grant from Korea Science and Engineering Foundation, a grant from the Ministry of Education (Genetic Engineering Program) and a grant from the Ministry of Science and Technology, South Korea.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.subject | DNA-BINDING DOMAIN | - |
dc.subject | ADP-RIBOSYLATION | - |
dc.subject | CALF THYMUS | - |
dc.subject | PROTEIN | - |
dc.subject | CELLS | - |
dc.subject | TOPOISOMERASE | - |
dc.subject | ASSOCIATION | - |
dc.subject | STIMULATION | - |
dc.subject | SUBSTRATE | - |
dc.subject | PROTEASES | - |
dc.title | Inhibition of homodimerization of poly(ADP-ribose) polymerase by its C-terminal cleavage products produced during apoptosis | - |
dc.type | Article | - |
dc.identifier.wosid | 000085913300094 | - |
dc.identifier.scopusid | 2-s2.0-0009990376 | - |
dc.type.rims | ART | - |
dc.citation.volume | 275 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 8121 | - |
dc.citation.endingpage | 8125 | - |
dc.citation.publicationname | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Joe, Cheol O | - |
dc.contributor.nonIdAuthor | Kim, JW | - |
dc.contributor.nonIdAuthor | Kim, K | - |
dc.contributor.nonIdAuthor | Kang, K | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DNA-BINDING DOMAIN | - |
dc.subject.keywordPlus | ADP-RIBOSYLATION | - |
dc.subject.keywordPlus | CALF THYMUS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TOPOISOMERASE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | SUBSTRATE | - |
dc.subject.keywordPlus | PROTEASES | - |
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